A general target selection method for crystallographic proteomics.

@article{citeulike:2884031, abstract = {: Increasing the success in obtaining structures and maximizing the value of the structures determined are the two major goals of target selection in structural proteomics. This chapter presents an efficient and flexible target selection procedure supplemented with a Web-based resource that is suitable for small- to large-scale structural genomics projects that use crystallography as the major means of structure determination. Based on three criteria, biological significance, structural novelty, and "crystallizability," the approach first removes (filters) targets that do not meet minimal criteria and then ranks the remaining targets based on their "crystallizability" estimates. This novel procedure was designed to maximize selection efficiency, and its prevailing criteria categories make it suitable for a broad range of structural proteomics projects.}, address = {Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.}, author = {Robin, G. and Cowieson, N. P. and Guncar, G. and Forwood, J. K. and Listwan, P. and Hume, D. A. and Kobe, B. and Martin, J. L. and Huber, T. }, citeulike-article-id = {2884031}, doi = {http://dx.doi.org/10.1007/978-1-60327-058-8\_2}, issn = {1064-3745}, journal = {Methods in molecular biology (Clifton, N.J.)}, keywords = {crystallography, proteomics, selection, structure, target}, pages = {27--35}, posted-at = {2008-06-12 01:02:41}, priority = {2}, title = {A general target selection method for crystallographic proteomics.}, url = {http://dx.doi.org/10.1007/978-1-60327-058-8\_2}, volume = {426}, year = {2008} }

TY - JOUR ID - citeulike:2884031 L3 - citeulike-article-id:2884031 TI - A general target selection method for crystallographic proteomics. JF - Methods in molecular biology (Clifton, N.J.) VL - 426 SP - 27 EP - 35 AD - Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. SN - 1064-3745 N2 - : Increasing the success in obtaining structures and maximizing the value of the structures determined are the two major goals of target selection in structural proteomics. This chapter presents an efficient and flexible target selection procedure supplemented with a Web-based resource that is suitable for small- to large-scale structural genomics projects that use crystallography as the major means of structure determination. Based on three criteria, biological significance, structural novelty, and "crystallizability," the approach first removes (filters) targets that do not meet minimal criteria and then ranks the remaining targets based on their "crystallizability" estimates. This novel procedure was designed to maximize selection efficiency, and its prevailing criteria categories make it suitable for a broad range of structural proteomics projects. KW - crystallography KW - proteomics KW - selection KW - structure KW - target AU - Robin, G AU - Cowieson, NP AU - Guncar, G AU - Forwood, JK AU - Listwan, P AU - Hume, DA AU - Kobe, B AU - Martin, JL AU - Huber, T PY - 2008/// UR - http://dx.doi.org/10.1007/978-1-60327-058-8_2 ER -