Magnetic Nanoparticle−Peptide Conjugates for in Vitro and in Vivo Targeting and Extraction of Cancer Cells

@article{citeulike:2986025, abstract = {Abstract: Magnetic cobalt spinel ferrite nanoparticles coated with biocompatible polygalacturonic acid were functionalized with ligands specific for targeting expressed EphA2 receptors on ovarian cancer cells. By using such magnetic nanoparticlepeptide conjugates, targeting and extraction of malignant cells were achieved with a magnetic field. Targeting ovarian cancer cells with receptor specific peptide-modified magnetic nanoparticles resulted in cell capture from a flow stream in vitro and from the peritoneal cavity of mice in vivo. Successful removal of metastatic cancer cells from the abdominal cavity and circulation using magnetic nanoparticle conjugates indicate the feasibility of a dialysis-like treatment and may improve long-term survival rates of ovarian cancer patients. This approach can be applied for fighting other cancers, such as leukemia, once the receptors on malignant cells are identified and the efficacy of targeting ligands is established.}, address = {School of Chemistry and Biochemistry, School of Biology, Ovarian Cancer Institute, Georgia Institute of Technology, Atlanta, Georgia 30332}, author = {Scarberry, Kenneth E. and Dickerson, Erin B. and Mcdonald, John F. and Zhang, John Z. }, citeulike-article-id = {2986025}, doi = {http://dx.doi.org/10.1021/ja801969b}, journal = {J. Am. Chem. Soc.}, keywords = {fluorescent-imaging, murine-model, peptide, polymer, prostate-specific-membrane-antigen, rhodamine, superparamagnetic-iron-oxide-nanoparticle}, month = {July}, posted-at = {2008-07-10 21:46:36}, priority = {2}, title = {Magnetic Nanoparticle\&\#x2212;Peptide Conjugates for in Vitro and in Vivo Targeting and Extraction of Cancer Cells}, url = {http://dx.doi.org/10.1021/ja801969b}, year = {2008} }

TY - JOUR ID - citeulike:2986025 L3 - citeulike-article-id:2986025 TI - Magnetic Nanoparticle−Peptide Conjugates for in Vitro and in Vivo Targeting and Extraction of Cancer Cells JF - J. Am. Chem. Soc. AD - School of Chemistry and Biochemistry, School of Biology, Ovarian Cancer Institute, Georgia Institute of Technology, Atlanta, Georgia 30332 N2 - Abstract: Magnetic cobalt spinel ferrite nanoparticles coated with biocompatible polygalacturonic acid were functionalized with ligands specific for targeting expressed EphA2 receptors on ovarian cancer cells. By using such magnetic nanoparticlepeptide conjugates, targeting and extraction of malignant cells were achieved with a magnetic field. Targeting ovarian cancer cells with receptor specific peptide-modified magnetic nanoparticles resulted in cell capture from a flow stream in vitro and from the peritoneal cavity of mice in vivo. Successful removal of metastatic cancer cells from the abdominal cavity and circulation using magnetic nanoparticle conjugates indicate the feasibility of a dialysis-like treatment and may improve long-term survival rates of ovarian cancer patients. This approach can be applied for fighting other cancers, such as leukemia, once the receptors on malignant cells are identified and the efficacy of targeting ligands is established. KW - fluorescent-imaging KW - murine-model KW - peptide KW - polymer KW - prostate-specific-membrane-antigen KW - rhodamine KW - superparamagnetic-iron-oxide-nanoparticle AU - Scarberry, Kenneth AU - Dickerson, Erin AU - Mcdonald, John AU - Zhang, John PY - 2008/07/09/ UR - http://dx.doi.org/10.1021/ja801969b ER -