Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix(TM)

@article{citeulike:2683770, abstract = {Gene expression profiling is rapidly becoming a mainstay of functional genomic studies. However, there have been relatively few studies of how the data from expression profiles integrate with more classic approaches to examine gene expression. This study used gene expression profiling of a portion of the genome of Saccharomyces cerevisiae to explore the impact of blocks in the isoprenoid biosynthetic pathway on the expression of genes and the regulation of this pathway. Approximately 50\% of the genes whose expression was altered by blocks in isoprenoid biosynthesis were genes previously known to participate in the pathway. In contrast to this simple correspondence, the regulatory patterns revealed by different blocks, and in particular by antifungal azoles, was complex in a manner not anticipated by earlier studies.--Dimster-Denk, D., J. Rine, J. Phillips, S. Scherer, P. Cundiff, K. DeBord, D. Gilliland, S. Hickman, A. Jarvis, L. Tong, and M. Ashby. Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reproter Matrix(TM). J. Lipid Res. 1999. 40: 850-860.}, author = {Dimster-Denk, Dago and Rine, Jasper and Phillips, John and Scherer, Stewart and Cundiff, Paige and Debord, Kristin and Gilliland, Doug and Hickman, Scott and Jarvis, Amy and Tong, Lisa and Ashby, Matthew }, citeulike-article-id = {2683770}, journal = {J. Lipid Res.}, keywords = {array, colony, yeast}, month = {May}, number = {5}, pages = {850--860}, posted-at = {2008-04-18 00:15:02}, priority = {3}, title = {Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix(TM)}, url = {http://www.jlr.org/cgi/content/abstract/40/5/850}, volume = {40}, year = {1999} }

TY - JOUR ID - citeulike:2683770 L3 - citeulike-article-id:2683770 TI - Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix(TM) JF - J. Lipid Res. VL - 40 IS - 5 SP - 850 EP - 860 N2 - Gene expression profiling is rapidly becoming a mainstay of functional genomic studies. However, there have been relatively few studies of how the data from expression profiles integrate with more classic approaches to examine gene expression. This study used gene expression profiling of a portion of the genome of Saccharomyces cerevisiae to explore the impact of blocks in the isoprenoid biosynthetic pathway on the expression of genes and the regulation of this pathway. Approximately 50% of the genes whose expression was altered by blocks in isoprenoid biosynthesis were genes previously known to participate in the pathway. In contrast to this simple correspondence, the regulatory patterns revealed by different blocks, and in particular by antifungal azoles, was complex in a manner not anticipated by earlier studies.--Dimster-Denk, D., J. Rine, J. Phillips, S. Scherer, P. Cundiff, K. DeBord, D. Gilliland, S. Hickman, A. Jarvis, L. Tong, and M. Ashby. Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reproter Matrix(TM). J. Lipid Res. 1999. 40: 850-860. KW - array KW - colony KW - yeast AU - Dimster-Denk, Dago AU - Rine, Jasper AU - Phillips, John AU - Scherer, Stewart AU - Cundiff, Paige AU - Debord, Kristin AU - Gilliland, Doug AU - Hickman, Scott AU - Jarvis, Amy AU - Tong, Lisa AU - Ashby, Matthew PY - 1999/05/01/ UR - http://www.jlr.org/cgi/content/abstract/40/5/850 ER -