Pre-mRNA splicing: a complex picture in higher definition.

@article{citeulike:2800422, abstract = {Intron excision from pre-mRNAs of higher eukaryotes requires a transition from splice-site recognition across short exons to organization of the spliceosome across long introns. Recently, insight into this transition has been provided and, in addition, it has been shown that an alternative splicing factor, the polypyrimidine-tract-binding protein, can exert its control on splice-site choice by blocking this key step in the assembly of the splicing machinery.}, address = {Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.}, author = {Schellenberg, Matthew J J. and Ritchie, Dustin B B. and Macmillan, Andrew M M. }, citeulike-article-id = {2800422}, doi = {10.1016/j.tibs.2008.04.004}, issn = {0968-0004}, journal = {Trends in biochemical sciences}, keywords = {transcription}, month = {May}, posted-at = {2008-05-15 02:02:26}, priority = {2}, title = {Pre-mRNA splicing: a complex picture in higher definition.}, url = {http://dx.doi.org/10.1016/j.tibs.2008.04.004}, year = {2008} }

TY - JOUR ID - citeulike:2800422 L3 - citeulike-article-id:2800422 TI - Pre-mRNA splicing: a complex picture in higher definition. JF - Trends in biochemical sciences AD - Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. SN - 0968-0004 N2 - Intron excision from pre-mRNAs of higher eukaryotes requires a transition from splice-site recognition across short exons to organization of the spliceosome across long introns. Recently, insight into this transition has been provided and, in addition, it has been shown that an alternative splicing factor, the polypyrimidine-tract-binding protein, can exert its control on splice-site choice by blocking this key step in the assembly of the splicing machinery. KW - transcription AU - Schellenberg, Matthew J AU - Ritchie, Dustin B AU - Macmillan, Andrew M PY - 2008/05/08/ UR - http://dx.doi.org/10.1016/j.tibs.2008.04.004 ER -