Molecular evolution of the RNA polymerase II CTD.

@article{citeulike:2800418, abstract = {In higher eukaryotes, an unusual C-terminal domain (CTD) is crucial to the function of RNA polymerase II in transcription. The CTD consists of multiple heptapeptide repeats; differences in the number of repeats between organisms and their degree of conservation have intrigued researchers for two decades. Here, we review the evolution of the CTD at the molecular level. Several primitive motifs have been integrated into compound heptads that can be readily amplified. The selection of phosphorylatable residues in the heptad repeat provided the opportunity for advanced gene regulation in eukaryotes. Current findings suggest that the CTD should be considered as a collection of continuous overlapping motifs as opposed to a specific functional unit defined by a heptad.}, address = {Institute for Clinical Molecular Biology and Tumour Genetics, Helmholtz Center for Environmental Health, Center for Integrated Protein Science (CiPSM), D-81377 Munich, Germany.}, author = {Chapman, Rob D D. and Heidemann, Martin and Hintermair, Corinna and Eick, Dirk }, citeulike-article-id = {2800418}, doi = {10.1016/j.tig.2008.03.010}, issn = {0168-9525}, journal = {Trends in genetics : TIG}, keywords = {molecular\_evolution, transcription}, month = {May}, posted-at = {2008-05-15 02:01:20}, priority = {2}, title = {Molecular evolution of the RNA polymerase II CTD.}, url = {http://dx.doi.org/10.1016/j.tig.2008.03.010}, year = {2008} }

TY - JOUR ID - citeulike:2800418 L3 - citeulike-article-id:2800418 TI - Molecular evolution of the RNA polymerase II CTD. JF - Trends in genetics : TIG AD - Institute for Clinical Molecular Biology and Tumour Genetics, Helmholtz Center for Environmental Health, Center for Integrated Protein Science (CiPSM), D-81377 Munich, Germany. SN - 0168-9525 N2 - In higher eukaryotes, an unusual C-terminal domain (CTD) is crucial to the function of RNA polymerase II in transcription. The CTD consists of multiple heptapeptide repeats; differences in the number of repeats between organisms and their degree of conservation have intrigued researchers for two decades. Here, we review the evolution of the CTD at the molecular level. Several primitive motifs have been integrated into compound heptads that can be readily amplified. The selection of phosphorylatable residues in the heptad repeat provided the opportunity for advanced gene regulation in eukaryotes. Current findings suggest that the CTD should be considered as a collection of continuous overlapping motifs as opposed to a specific functional unit defined by a heptad. KW - molecular_evolution KW - transcription AU - Chapman, Rob D AU - Heidemann, Martin AU - Hintermair, Corinna AU - Eick, Dirk PY - 2008/05/08/ UR - http://dx.doi.org/10.1016/j.tig.2008.03.010 ER -