Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta

@article{citeulike:2772579, abstract = {Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneural gene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization. Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells. These observations support a model for Notch activation where the Delta-Notch interaction is followed by endocytosis of Delta and transendocytosis of the Notch extracellular domain by the signaling cell. This facilitates intramembranous cleavage of the remaining Notch receptor, release of the Notch intracellular fragment, and activation of target genes in neighboring cells.}, author = {Itoh, Motoyuki and Kim, Cheol-Hee and Palardy, Gregory and Oda, Takaya and Jiang, Yun-Jin and Maust, Donovan and Yeo, Sang-Yeob and Lorick, Kevin and Wright, Gavin J. and Ariza-Mcnaughton, Linda and Weissman, Allan M. and Lewis, Julian and Chandrasekharappa, Settara C. and Chitnis, Ajay B. }, citeulike-article-id = {2772579}, doi = {10.1016/S1534-5807(02)00409-4}, journal = {Developmental Cell}, keywords = {h, mindbomb, to\_print}, month = {January}, number = {1}, pages = {67--82}, posted-at = {2008-05-08 16:35:08}, priority = {2}, title = {Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta}, url = {http://dx.doi.org/10.1016/S1534-5807(02)00409-4}, volume = {4}, year = {2003} }

TY - JOUR ID - citeulike:2772579 L3 - citeulike-article-id:2772579 TI - Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta JF - Developmental Cell VL - 4 IS - 1 SP - 67 EP - 82 N2 - Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneural gene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization. Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells. These observations support a model for Notch activation where the Delta-Notch interaction is followed by endocytosis of Delta and transendocytosis of the Notch extracellular domain by the signaling cell. This facilitates intramembranous cleavage of the remaining Notch receptor, release of the Notch intracellular fragment, and activation of target genes in neighboring cells. KW - h KW - mindbomb KW - to_print AU - Itoh, Motoyuki AU - Kim, Cheol-Hee AU - Palardy, Gregory AU - Oda, Takaya AU - Jiang, Yun-Jin AU - Maust, Donovan AU - Yeo, Sang-Yeob AU - Lorick, Kevin AU - Wright, Gavin AU - Ariza-Mcnaughton, Linda AU - Weissman, Allan AU - Lewis, Julian AU - Chandrasekharappa, Settara AU - Chitnis, Ajay PY - 2003/01// UR - http://dx.doi.org/10.1016/S1534-5807(02)00409-4 ER -