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Notch Signaling: Endocytosis Makes Delta Signal Better

by: Roland Le Borgne, Francois Schweisguth
Current Biology, Vol. 13, No. 7. (1 April 2003), pp. R273-R275.

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Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.


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