Intron Size and Exon Evolution in Drosophila

by: Gabriel Marais, Pierre Nouvellet, Peter D Keightley, Brian Charlesworth

Genetics, Vol. 170, No. 1. (1 May 2005), pp. 481-485.

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Abstract

We have found a negative correlation between evolutionary rate at the protein level (as measured by dN) and intron size in Drosophila. Although such a relation is expected if introns reduce Hill-Robertson interference within genes, it seems more likely to be explained by the higher abundance of cis-regulatory elements in introns (especially first introns) in genes under strong selective constraints. 10.1534/genetics.104.037333

@article{citeulike:683160, abstract = {We have found a negative correlation between evolutionary rate at the protein level (as measured by dN) and intron size in Drosophila. Although such a relation is expected if introns reduce Hill-Robertson interference within genes, it seems more likely to be explained by the higher abundance of cis-regulatory elements in introns (especially first introns) in genes under strong selective constraints. 10.1534/genetics.104.037333}, author = {Marais, Gabriel and Nouvellet, Pierre and Keightley, Peter D. and Charlesworth, Brian }, citeulike-article-id = {683160}, doi = {http://dx.doi.org/10.1534/genetics.104.037333}, journal = {Genetics}, keywords = {intron\_size}, month = {May}, number = {1}, pages = {481--485}, posted-at = {2007-05-30 14:36:45}, priority = {2}, title = {Intron Size and Exon Evolution in Drosophila}, url = {http://dx.doi.org/10.1534/genetics.104.037333}, volume = {170}, year = {2005} }

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TY - JOUR ID - citeulike:683160 L3 - citeulike-article-id:683160 TI - Intron Size and Exon Evolution in Drosophila JF - Genetics VL - 170 IS - 1 SP - 481 EP - 485 N2 - We have found a negative correlation between evolutionary rate at the protein level (as measured by dN) and intron size in Drosophila. Although such a relation is expected if introns reduce Hill-Robertson interference within genes, it seems more likely to be explained by the higher abundance of cis-regulatory elements in introns (especially first introns) in genes under strong selective constraints. 10.1534/genetics.104.037333 KW - intron_size AU - Marais, Gabriel AU - Nouvellet, Pierre AU - Keightley, Peter AU - Charlesworth, Brian PY - 2005/05/01/ UR - http://dx.doi.org/10.1534/genetics.104.037333 ER -

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