On the Incidence of Intron Loss and Gain in Paralogous Gene Families

@article{citeulike:1318672, abstract = {Understanding gene duplication and gene structure evolution are fundamental goals of molecular evolutionary biology. A previous study (Babenko et al. 2004. Prevalance of intron gain over intron loss in the evolution of paralogous gene families. Nucleic Acids Res. 32: 3724-3733) utilized Dollo parsimony to infer spliceosomal intron losses and gains in paralogous gene families, and concluded that there was a general excess of gains over losses. This result contrasts with patterns in orthologous genes, in which most lineages show an excess of intron losses over gains, suggesting the possibility of fundamentally different modes of intron evolution between orthologous and paralogous genes. We further studied the data and found a low level of intron position conservation with outgroups, leading to problems with using Dollo parsimony to analyze the data. Statistical reanalysis of the data suggests instead that intron losses have outnumbered intron gains in paralogous gene families. 10.1093/molbev/msm082}, author = {Roy, Scott W. and Penny, David }, citeulike-article-id = {1318672}, doi = {http://dx.doi.org/10.1093/molbev/msm082}, journal = {Mol Biol Evol}, keywords = {gain, intron, loss}, month = {April}, pages = {msm082+}, posted-at = {2007-08-20 10:06:45}, priority = {2}, title = {On the Incidence of Intron Loss and Gain in Paralogous Gene Families}, url = {http://dx.doi.org/10.1093/molbev/msm082}, year = {2007} }

TY - JOUR ID - citeulike:1318672 L3 - citeulike-article-id:1318672 TI - On the Incidence of Intron Loss and Gain in Paralogous Gene Families JF - Mol Biol Evol SP - msm082 N2 - Understanding gene duplication and gene structure evolution are fundamental goals of molecular evolutionary biology. A previous study (Babenko et al. 2004. Prevalance of intron gain over intron loss in the evolution of paralogous gene families. Nucleic Acids Res. 32: 3724-3733) utilized Dollo parsimony to infer spliceosomal intron losses and gains in paralogous gene families, and concluded that there was a general excess of gains over losses. This result contrasts with patterns in orthologous genes, in which most lineages show an excess of intron losses over gains, suggesting the possibility of fundamentally different modes of intron evolution between orthologous and paralogous genes. We further studied the data and found a low level of intron position conservation with outgroups, leading to problems with using Dollo parsimony to analyze the data. Statistical reanalysis of the data suggests instead that intron losses have outnumbered intron gains in paralogous gene families. 10.1093/molbev/msm082 KW - gain KW - intron KW - loss AU - Roy, Scott AU - Penny, David PY - 2007/04/29/ UR - http://dx.doi.org/10.1093/molbev/msm082 ER -