Methylation, mutation and cancer.

@article{citeulike:2676045, abstract = {The fifth base in human DNA, 5-methylcytosine, is inherently mutagenic. This has led to marked changes in the distribution of the CpG methyl acceptor site and an 80\% depletion in its frequency of occurrence in vertebrate DNA. The coding regions of many genes contain CpGs which are methylated in sperm and serve as hot spots for mutation in human genetic diseases. Fully 30-40\% of all human germline point mutations are thought to be methylation induced even though the CpG dinucleotide is under-represented and efficient cellular repair systems exist. Importantly, tumor suppressor genes such as p53 also contain methylated CpGs and these serve as hot spots for mutations in some, but not all, human cancers. Comparison of the spectrum of mutations present in this gene in different human cancers allows for predictions to be made on the molecular mechanisms of tumorigenesis.}, address = {Kenneth Norris Jr. Comprehensive Cancer Center, USC School of Medicine, Los Angeles 90033.}, author = {Jones, P. A. and Rideout, W. M. and Shen, J. C. and Spruck, C. H. and Tsai, Y. C. }, citeulike-article-id = {2676045}, doi = {http://dx.doi.org/10.1002/bies.950140107}, issn = {0265-9247}, journal = {BioEssays : news and reviews in molecular, cellular and developmental biology}, keywords = {cpg\_islands}, month = {January}, number = {1}, pages = {33--36}, posted-at = {2008-04-16 05:42:18}, priority = {2}, title = {Methylation, mutation and cancer.}, url = {http://dx.doi.org/10.1002/bies.950140107}, volume = {14}, year = {1992} }

TY - JOUR ID - citeulike:2676045 L3 - citeulike-article-id:2676045 TI - Methylation, mutation and cancer. JF - BioEssays : news and reviews in molecular, cellular and developmental biology VL - 14 IS - 1 SP - 33 EP - 36 AD - Kenneth Norris Jr. Comprehensive Cancer Center, USC School of Medicine, Los Angeles 90033. SN - 0265-9247 N2 - The fifth base in human DNA, 5-methylcytosine, is inherently mutagenic. This has led to marked changes in the distribution of the CpG methyl acceptor site and an 80% depletion in its frequency of occurrence in vertebrate DNA. The coding regions of many genes contain CpGs which are methylated in sperm and serve as hot spots for mutation in human genetic diseases. Fully 30-40% of all human germline point mutations are thought to be methylation induced even though the CpG dinucleotide is under-represented and efficient cellular repair systems exist. Importantly, tumor suppressor genes such as p53 also contain methylated CpGs and these serve as hot spots for mutations in some, but not all, human cancers. Comparison of the spectrum of mutations present in this gene in different human cancers allows for predictions to be made on the molecular mechanisms of tumorigenesis. KW - cpg_islands AU - Jones, PA AU - Rideout, WM AU - Shen, JC AU - Spruck, CH AU - Tsai, YC PY - 1992/01// UR - http://dx.doi.org/10.1002/bies.950140107 ER -