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DNA methylation and the frequency of CpG in animal DNA

by: Adrian P Bird
Nucl. Acids Res., Vol. 8, No. 7. (11 April 1980), pp. 1499-1504.


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An analysis of nearest neighbour dinucleotide frequencies and the level of DNA methylation in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate abnormally frequently to T. This tendency is the likely cause of the CpG deficiency in heavily methylated genomes. 10.1093/nar/8.7.1499


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