Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery.

by: AD Crawford, CV Esguerra, PA de Witte

Planta medica, Vol. 74, No. 6. (May 2008), pp. 624-632.

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Abstract

Emerging challenges within the current drug discovery paradigm are prompting renewed interest in natural products as a source of novel, bioactive small molecules. With the recent validation of zebrafish as a biomedically relevant model for functional genomics and in vivo drug discovery, the zebrafish bioassay-guided identification of natural products may be an attractive strategy to generate new lead compounds in a number of indication areas. Here, we review recent natural product research using zebrafish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products.

@article{citeulike:3102923, abstract = {Emerging challenges within the current drug discovery paradigm are prompting renewed interest in natural products as a source of novel, bioactive small molecules. With the recent validation of zebrafish as a biomedically relevant model for functional genomics and in vivo drug discovery, the zebrafish bioassay-guided identification of natural products may be an attractive strategy to generate new lead compounds in a number of indication areas. Here, we review recent natural product research using zebrafish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products.}, address = {Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium. alexander.crawford@pharm.kuleuven.be}, author = {Crawford, A. D. and Esguerra, C. V. and de Witte, P. A. }, citeulike-article-id = {3102923}, issn = {0032-0943}, journal = {Planta medica}, keywords = {herb, zebrafish}, month = {May}, number = {6}, pages = {624--632}, posted-at = {2008-08-09 01:50:48}, priority = {2}, title = {Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18584811}, volume = {74}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:3102923 L3 - citeulike-article-id:3102923 N2 - Emerging challenges within the current drug discovery paradigm are prompting renewed interest in natural products as a source of novel, bioactive small molecules. With the recent validation of zebrafish as a biomedically relevant model for functional genomics and in vivo drug discovery, the zebrafish bioassay-guided identification of natural products may be an attractive strategy to generate new lead compounds in a number of indication areas. Here, we review recent natural product research using zebrafish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products. IS - 6 JF - Planta medica SN - 0032-0943 AD - Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium. alexander.crawford@pharm.kuleuven.be EP - 632 TI - Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery. VL - 74 SP - 624 KW - herb KW - zebrafish AU - Crawford, AD AU - Esguerra, CV AU - de Witte, PA PY - 2008/05// UR - http://view.ncbi.nlm.nih.gov/pubmed/18584811 ER -

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