Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World

@article{citeulike:2437439, abstract = {Abstract: We present ABCD, an integrated drug discovery informatics platform developed at Johnson \& Johnson Pharmaceutical Research \& Development, L.L.C. ABCD is an attempt to bridge multiple continents, data systems, and cultures using modern information technology and to provide scientists with tools that allow them to analyze multifactorial SAR and make informed, data-driven decisions. The system consists of three major components: (1) a data warehouse, which combines data from multiple chemical and pharmacological transactional databases, designed for supreme query performance; (2) a state-of-the-art application suite, which facilitates data upload, retrieval, mining, and reporting, and (3) a workspace, which facilitates collaboration and data sharing by allowing users to share queries, templates, results, and reports across project teams, campuses, and other organizational units. Chemical intelligence, performance, and analytical sophistication lie at the heart of the new system, which was developed entirely in-house. ABCD is used routinely by more than 1000 scientists around the world and is rapidly expanding into other functional areas within the J\&J organization.}, address = {Information Technology, Johnson \& Johnson Pharmaceutical Research \& Development, L.L.C., 665 Stockton Drive, Exton, Pennsylvania 19341, Information Technology, Johnson \& Johnson Pharmaceutical Research \& Development division of Janssen Pharmaceutica N.V., Turnhoutsweg 30, 2340 Beerse, Belgium, and Bioinformatics, Johnson \& Johnson Pharmaceutical Research \& Development, L.L.C., 3210 Merryfield Row, San Diego, California 92121}, author = {Agrafiotis, D. K. and Alex, S. and Dai, H. and Derkinderen, A. and Farnum, M. and Gates, P. and Izrailev, S. and Jaeger, E. P. and Konstant, P. and Leung, A. and Lobanov, V. S. and Marichal, P. and Martin, D. and Rassokhin, D. N. and Shemanarev, M. and Skalkin, A. and Stong, J. and Tabruyn, T. and Vermeiren, M. and Wan, J. and Xu, X. Y. and Yao, X. }, citeulike-article-id = {2437439}, doi = {http://dx.doi.org/10.1021/ci700267w}, journal = {J. Chem. Inf. Model.}, keywords = {cheminformatics}, month = {November}, number = {6}, pages = {1999--2014}, posted-at = {2008-02-27 16:08:41}, priority = {2}, title = {Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World}, url = {http://dx.doi.org/10.1021/ci700267w}, volume = {47}, year = {2007} }

TY - JOUR ID - citeulike:2437439 L3 - citeulike-article-id:2437439 N2 - Abstract: We present ABCD, an integrated drug discovery informatics platform developed at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. ABCD is an attempt to bridge multiple continents, data systems, and cultures using modern information technology and to provide scientists with tools that allow them to analyze multifactorial SAR and make informed, data-driven decisions. The system consists of three major components: (1) a data warehouse, which combines data from multiple chemical and pharmacological transactional databases, designed for supreme query performance; (2) a state-of-the-art application suite, which facilitates data upload, retrieval, mining, and reporting, and (3) a workspace, which facilitates collaboration and data sharing by allowing users to share queries, templates, results, and reports across project teams, campuses, and other organizational units. Chemical intelligence, performance, and analytical sophistication lie at the heart of the new system, which was developed entirely in-house. ABCD is used routinely by more than 1000 scientists around the world and is rapidly expanding into other functional areas within the J&J organization. IS - 6 JF - J. Chem. Inf. Model. AD - Information Technology, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 665 Stockton Drive, Exton, Pennsylvania 19341, Information Technology, Johnson & Johnson Pharmaceutical Research & Development division of Janssen Pharmaceutica N.V., Turnhoutsweg 30, 2340 Beerse, Belgium, and Bioinformatics, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, California 92121 EP - 2014 TI - Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World VL - 47 SP - 1999 KW - cheminformatics AU - Agrafiotis, DK AU - Alex, S AU - Dai, H AU - Derkinderen, A AU - Farnum, M AU - Gates, P AU - Izrailev, S AU - Jaeger, EP AU - Konstant, P AU - Leung, A AU - Lobanov, VS AU - Marichal, P AU - Martin, D AU - Rassokhin, DN AU - Shemanarev, M AU - Skalkin, A AU - Stong, J AU - Tabruyn, T AU - Vermeiren, M AU - Wan, J AU - Xu, XY AU - Yao, X PY - 2007/11/26/ UR - http://dx.doi.org/10.1021/ci700267w ER -