Toxicogenomics: a new revolution in drug safety.

by: AL Castle, MP Carver, DL Mendrick

Drug Discov Today, Vol. 7, No. 13. (1 July 2002), pp. 728-736.

View FullText article

Pubmed, Hubmed

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

jdiggans

Find related articles with these CiteULike tags

review, toxicogenomics

Abstract

New drugs are screened for adverse reactions using a laborious, costly process and still some promising therapeutics are withdrawn from the marketplace because of unforeseen human toxicity. Novel higher throughput methods in toxicology need to be developed. These new approaches should provide more insight into potential human toxicity than current methods. Toxicogenomics, the examination of changes in gene expression following exposure to a toxicant, offers the potential to identify a human toxicant earlier in drug development and to detect human-specific toxicants that cause no adverse reaction in rats.

@article{citeulike:900383, abstract = {New drugs are screened for adverse reactions using a laborious, costly process and still some promising therapeutics are withdrawn from the marketplace because of unforeseen human toxicity. Novel higher throughput methods in toxicology need to be developed. These new approaches should provide more insight into potential human toxicity than current methods. Toxicogenomics, the examination of changes in gene expression following exposure to a toxicant, offers the potential to identify a human toxicant earlier in drug development and to detect human-specific toxicants that cause no adverse reaction in rats.}, address = {Gene Logic, Gaithersburg, MD, USA.}, author = {Castle, A. L. and Carver, M. P. and Mendrick, D. L. }, citeulike-article-id = {900383}, issn = {1359-6446}, journal = {Drug Discov Today}, keywords = {review, toxicogenomics}, month = {July}, number = {13}, pages = {728--736}, posted-at = {2006-10-17 00:41:43}, priority = {4}, title = {Toxicogenomics: a new revolution in drug safety.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12110229}, volume = {7}, year = {2002} }

RIS record

TY - JOUR ID - citeulike:900383 L3 - citeulike-article-id:900383 TI - Toxicogenomics: a new revolution in drug safety. JF - Drug Discov Today VL - 7 IS - 13 SP - 728 EP - 736 AD - Gene Logic, Gaithersburg, MD, USA. SN - 1359-6446 N2 - New drugs are screened for adverse reactions using a laborious, costly process and still some promising therapeutics are withdrawn from the marketplace because of unforeseen human toxicity. Novel higher throughput methods in toxicology need to be developed. These new approaches should provide more insight into potential human toxicity than current methods. Toxicogenomics, the examination of changes in gene expression following exposure to a toxicant, offers the potential to identify a human toxicant earlier in drug development and to detect human-specific toxicants that cause no adverse reaction in rats. KW - review KW - toxicogenomics AU - Castle, AL AU - Carver, MP AU - Mendrick, DL PY - 2002/07/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12110229 ER -

RIS BibTeX