Genome-wide Analysis of Alternative Pre-mRNA Splicing

@article{citeulike:2229782, abstract = {Alternative splicing of mRNA precursors allows the synthesis of multiple mRNAs from a single primary transcript, significantly expanding the information content and regulatory possibilities of higher eukaryotic genomes. High-throughput enabling technologies, particularly large-scale sequencing and splicing-sensitive microarrays, are providing unprecedented opportunities to address key questions in this field. The picture emerging from these pioneering studies is that alternative splicing affects most human genes and a significant fraction of the genes in other multicellular organisms, with the potential to greatly influence the evolution of complex genomes. A combinatorial code of regulatory signals and factors can deploy physiologically coherent programs of alternative splicing that are distinct from those regulated at other steps of gene expression. Pre-mRNA splicing and its regulation play important roles in human pathologies, and genome-wide analyses in this area are paving the way for improved diagnostic tools and for the identification of novel and more specific pharmaceutical targets. 10.1074/jbc.R700033200}, author = {Dov, Claudia B. and Hartmann, Britta and Lundgren, Josefin and Valcarcel, Juan }, citeulike-article-id = {2229782}, doi = {http://dx.doi.org/10.1074/jbc.R700033200}, journal = {J. Biol. Chem.}, keywords = {splicing}, month = {January}, number = {3}, pages = {1229--1233}, posted-at = {2008-01-14 10:21:34}, priority = {2}, title = {Genome-wide Analysis of Alternative Pre-mRNA Splicing}, url = {http://dx.doi.org/10.1074/jbc.R700033200}, volume = {283}, year = {2008} }

TY - JOUR ID - citeulike:2229782 L3 - citeulike-article-id:2229782 N2 - Alternative splicing of mRNA precursors allows the synthesis of multiple mRNAs from a single primary transcript, significantly expanding the information content and regulatory possibilities of higher eukaryotic genomes. High-throughput enabling technologies, particularly large-scale sequencing and splicing-sensitive microarrays, are providing unprecedented opportunities to address key questions in this field. The picture emerging from these pioneering studies is that alternative splicing affects most human genes and a significant fraction of the genes in other multicellular organisms, with the potential to greatly influence the evolution of complex genomes. A combinatorial code of regulatory signals and factors can deploy physiologically coherent programs of alternative splicing that are distinct from those regulated at other steps of gene expression. Pre-mRNA splicing and its regulation play important roles in human pathologies, and genome-wide analyses in this area are paving the way for improved diagnostic tools and for the identification of novel and more specific pharmaceutical targets. 10.1074/jbc.R700033200 IS - 3 JF - J. Biol. Chem. EP - 1233 TI - Genome-wide Analysis of Alternative Pre-mRNA Splicing VL - 283 SP - 1229 KW - splicing AU - Dov, Claudia AU - Hartmann, Britta AU - Lundgren, Josefin AU - Valcarcel, Juan PY - 2008/January/18/ UR - http://dx.doi.org/10.1074/jbc.R700033200 ER -