Ongoing in Vivo Experience Triggers Synaptic Metaplasticity in the Neocortex

@article{citeulike:2194970, abstract = {In vivo experience can occlude subsequent induction of long-term potentiation and enhance long-term depression of synaptic responses. Although a reduced capacity for synaptic strengthening may function to prevent excessive excitation, such an effect paradoxically implies that continued experience or training should not improve and may even degrade neural representations. In mice, we examined the effect of ongoing whisker stimulation on synaptic strengthening at layer 4-2/3 synapses in the barrel cortex. Although N-methyl-D-aspartate receptors were required to initiate strengthening, they subsequently suppressed further potentiation at these synapses in vitro and in vivo. Despite this transition, synaptic strengthening continued with additional sensory activity but instead required the activation of metabotropic glutamate receptors, suggesting a mechanism by which continued experience can result in increasing synaptic strength over time. 10.1126/science.1143808}, author = {Clem, Roger L. and Celikel, Tansu and Barth, Alison L. }, citeulike-article-id = {2194970}, doi = {10.1126/science.1143808}, journal = {Science}, keywords = {barrel, experience, lt, mouse, plasticity}, month = {January}, number = {5859}, pages = {101--104}, posted-at = {2008-04-14 17:57:36}, priority = {5}, title = {Ongoing in Vivo Experience Triggers Synaptic Metaplasticity in the Neocortex}, url = {http://dx.doi.org/10.1126/science.1143808}, volume = {319}, year = {2008} }

TY - JOUR ID - citeulike:2194970 L3 - citeulike-article-id:2194970 TI - Ongoing in Vivo Experience Triggers Synaptic Metaplasticity in the Neocortex JF - Science VL - 319 IS - 5859 SP - 101 EP - 104 N2 - In vivo experience can occlude subsequent induction of long-term potentiation and enhance long-term depression of synaptic responses. Although a reduced capacity for synaptic strengthening may function to prevent excessive excitation, such an effect paradoxically implies that continued experience or training should not improve and may even degrade neural representations. In mice, we examined the effect of ongoing whisker stimulation on synaptic strengthening at layer 4-2/3 synapses in the barrel cortex. Although N-methyl-D-aspartate receptors were required to initiate strengthening, they subsequently suppressed further potentiation at these synapses in vitro and in vivo. Despite this transition, synaptic strengthening continued with additional sensory activity but instead required the activation of metabotropic glutamate receptors, suggesting a mechanism by which continued experience can result in increasing synaptic strength over time. 10.1126/science.1143808 KW - barrel KW - experience KW - lt KW - mouse KW - plasticity AU - Clem, Roger AU - Celikel, Tansu AU - Barth, Alison PY - 2008/01/04/ UR - http://dx.doi.org/10.1126/science.1143808 ER -