Multilevel Regulation of Gene Expression by MicroRNAs

by: Eugene V Makeyev, Tom Maniatis

Science, Vol. 319, No. 5871. (28 March 2008), pp. 1789-1790.

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Abstract

MicroRNAs (miRNAs) are [~]22-nucleotide-long noncoding RNAs that normally function by suppressing translation and destabilizing messenger RNAs bearing complementary target sequences. Some miRNAs are expressed in a cell- or tissue-specific manner and may contribute to the establishment and/or maintenance of cellular identity. Recent studies indicate that tissue-specific miRNAs may function at multiple hierarchical levels of gene regulatory networks, from targeting hundreds of effector genes incompatible with the differentiated state to controlling the levels of global regulators of transcription and alternative pre-mRNA splicing. This multilevel regulation may allow individual miRNAs to profoundly affect the gene expression program of differentiated cells. 10.1126/science.1152326

@article{citeulike:2607640, abstract = {MicroRNAs (miRNAs) are [~]22-nucleotide-long noncoding RNAs that normally function by suppressing translation and destabilizing messenger RNAs bearing complementary target sequences. Some miRNAs are expressed in a cell- or tissue-specific manner and may contribute to the establishment and/or maintenance of cellular identity. Recent studies indicate that tissue-specific miRNAs may function at multiple hierarchical levels of gene regulatory networks, from targeting hundreds of effector genes incompatible with the differentiated state to controlling the levels of global regulators of transcription and alternative pre-mRNA splicing. This multilevel regulation may allow individual miRNAs to profoundly affect the gene expression program of differentiated cells. 10.1126/science.1152326}, author = {Makeyev, Eugene V. and Maniatis, Tom }, citeulike-article-id = {2607640}, doi = {10.1126/science.1152326}, journal = {Science}, keywords = {mirna, transcriptional\_regulation}, month = {March}, number = {5871}, pages = {1789--1790}, posted-at = {2008-04-01 07:19:27}, priority = {2}, title = {Multilevel Regulation of Gene Expression by MicroRNAs}, url = {http://dx.doi.org/10.1126/science.1152326}, volume = {319}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2607640 L3 - citeulike-article-id:2607640 TI - Multilevel Regulation of Gene Expression by MicroRNAs JF - Science VL - 319 IS - 5871 SP - 1789 EP - 1790 N2 - MicroRNAs (miRNAs) are [~]22-nucleotide-long noncoding RNAs that normally function by suppressing translation and destabilizing messenger RNAs bearing complementary target sequences. Some miRNAs are expressed in a cell- or tissue-specific manner and may contribute to the establishment and/or maintenance of cellular identity. Recent studies indicate that tissue-specific miRNAs may function at multiple hierarchical levels of gene regulatory networks, from targeting hundreds of effector genes incompatible with the differentiated state to controlling the levels of global regulators of transcription and alternative pre-mRNA splicing. This multilevel regulation may allow individual miRNAs to profoundly affect the gene expression program of differentiated cells. 10.1126/science.1152326 KW - mirna KW - transcriptional_regulation AU - Makeyev, Eugene AU - Maniatis, Tom PY - 2008/03/28/ UR - http://dx.doi.org/10.1126/science.1152326 ER -

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