Amplifying tumour-specific replication lesions by DNA repair inhibitors - A new era in targeted cancer therapy

@article{citeulike:2961475, abstract = {Many anti-cancer drugs used in the clinic today damage DNA, resulting in cell death either directly or following DNA replication. Many anti-cancer drugs are exclusively toxic to replicating cells and toxic lesions are formed when a replication fork encounters a damaged DNA template. Recent work shows that replication lesions, similar to those produced during anti-cancer therapy, are commonly associated with cancer aetiology. DNA replication lesions are present in cancer cells owing to oncogene expression, hypoxia or defects in the DNA damage response or DNA repair. Here, I review how novel therapies can exploit endogenous replication lesions in cancer cells and convert them to toxic lesions. The aim of these therapies is to produce similar lesions to those produced by DNA damaging anti-cancer drugs. The difference is that the lesions will be cancer-specific and produce milder side-effects in non-cancerous cells.}, author = {Helleday, Thomas }, citeulike-article-id = {2961475}, doi = {http://dx.doi.org/10.1016/j.ejca.2008.02.044}, journal = {European Journal of Cancer}, month = {May}, number = {7}, pages = {921--927}, posted-at = {2008-07-03 23:54:00}, priority = {2}, title = {Amplifying tumour-specific replication lesions by DNA repair inhibitors - A new era in targeted cancer therapy}, url = {http://dx.doi.org/10.1016/j.ejca.2008.02.044}, volume = {44}, year = {2008} }

TY - JOUR ID - citeulike:2961475 L3 - citeulike-article-id:2961475 TI - Amplifying tumour-specific replication lesions by DNA repair inhibitors - A new era in targeted cancer therapy JF - European Journal of Cancer VL - 44 IS - 7 SP - 921 EP - 927 N2 - Many anti-cancer drugs used in the clinic today damage DNA, resulting in cell death either directly or following DNA replication. Many anti-cancer drugs are exclusively toxic to replicating cells and toxic lesions are formed when a replication fork encounters a damaged DNA template. Recent work shows that replication lesions, similar to those produced during anti-cancer therapy, are commonly associated with cancer aetiology. DNA replication lesions are present in cancer cells owing to oncogene expression, hypoxia or defects in the DNA damage response or DNA repair. Here, I review how novel therapies can exploit endogenous replication lesions in cancer cells and convert them to toxic lesions. The aim of these therapies is to produce similar lesions to those produced by DNA damaging anti-cancer drugs. The difference is that the lesions will be cancer-specific and produce milder side-effects in non-cancerous cells. AU - Helleday, Thomas PY - 2008/05// UR - http://dx.doi.org/10.1016/j.ejca.2008.02.044 ER -