Illuminating the silence: understanding the structure and function of small RNAs

by: Tariq M Rana

Nature Reviews Molecular Cell Biology, Vol. 8, No. 1., pp. 23-36.

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Abstract

RNA interference (RNAi) is triggered by double-stranded RNA helices that have been introduced exogenously into cells as small interfering (si)RNAs or that have been produced endogenously from small non-coding RNAs known as microRNAs (miRNAs). RNAi has become a standard experimental tool and its therapeutic potential is being aggressively harnessed. Understanding the structure and function of small RNAs, such as siRNAs and miRNAs, that trigger RNAi has shed light on the RNAi machinery. In particular, it has highlighted the assembly and function of the RNA-induced silencing complex (RISC), and has provided guidelines to efficiently silence genes for biological research and therapeutic applications of RNAi.

@article{citeulike:1005645, abstract = {RNA interference (RNAi) is triggered by double-stranded RNA helices that have been introduced exogenously into cells as small interfering (si)RNAs or that have been produced endogenously from small non-coding RNAs known as microRNAs (miRNAs). RNAi has become a standard experimental tool and its therapeutic potential is being aggressively harnessed. Understanding the structure and function of small RNAs, such as siRNAs and miRNAs, that trigger RNAi has shed light on the RNAi machinery. In particular, it has highlighted the assembly and function of the RNA-induced silencing complex (RISC), and has provided guidelines to efficiently silence genes for biological research and therapeutic applications of RNAi.}, author = {Rana, Tariq M. }, citeulike-article-id = {1005645}, doi = {http://dx.doi.org/10.1038/nrm2085}, issn = {1471-0072}, journal = {Nature Reviews Molecular Cell Biology}, keywords = {microrna, review, sirna}, number = {1}, pages = {23--36}, posted-at = {2008-06-24 10:59:32}, priority = {2}, publisher = {Nature Publishing Group}, title = {Illuminating the silence: understanding the structure and function of small RNAs}, url = {http://dx.doi.org/10.1038/nrm2085}, volume = {8} }

RIS record

TY - JOUR ID - citeulike:1005645 L3 - citeulike-article-id:1005645 TI - Illuminating the silence: understanding the structure and function of small RNAs JF - Nature Reviews Molecular Cell Biology VL - 8 IS - 1 SP - 23 EP - 36 PB - Nature Publishing Group SN - 1471-0072 N2 - RNA interference (RNAi) is triggered by double-stranded RNA helices that have been introduced exogenously into cells as small interfering (si)RNAs or that have been produced endogenously from small non-coding RNAs known as microRNAs (miRNAs). RNAi has become a standard experimental tool and its therapeutic potential is being aggressively harnessed. Understanding the structure and function of small RNAs, such as siRNAs and miRNAs, that trigger RNAi has shed light on the RNAi machinery. In particular, it has highlighted the assembly and function of the RNA-induced silencing complex (RISC), and has provided guidelines to efficiently silence genes for biological research and therapeutic applications of RNAi. KW - microrna KW - review KW - sirna AU - Rana, Tariq UR - http://dx.doi.org/10.1038/nrm2085 ER -

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