Chromatin Insulators.

@article{citeulike:836713, abstract = {Active and silenced chromatin domains are often in close juxtaposition to one another and enhancer and silencer elements operate over large distances to regulate the genes in these domains. The lack of promiscuity in the function of these elements suggests that active mechanisms exist to restrict their activity. Insulators are DNA elements that restrict the effects of long-range regulatory elements. Studies on different insulators from different organisms have identified common themes in their mode of action. Numerous insulators map to promoters of genes or have binding sites for transcription factors and like active chromatin hubs and silenced loci, insulators also cluster in the nucleus. These results bring into focus potential conserved mechanisms by which these elements might function in the nucleus. Expected online publication date for the Annual Review of Genetics Volume 40 is November 3, 2006. Please see http://www.annualreviews.org/catalog/pub\_dates.asp for revised estimates.}, address = {Unit on Chromatin and Transcription, NICHD/NIH, Bethesda, MD 20892.}, author = {Valenzuela, Lourdes and Kamakaka, Rohinton T T. }, citeulike-article-id = {836713}, doi = {10.1146/annurev.genet.39.073003.113546}, issn = {0066-4197}, journal = {Annu Rev Genet}, keywords = {chromatin, domains, insulators, review}, month = {September}, posted-at = {2006-09-08 19:22:32}, priority = {2}, title = {Chromatin Insulators.}, url = {http://dx.doi.org/10.1146/annurev.genet.39.073003.113546}, year = {2006} }

TY - JOUR ID - citeulike:836713 L3 - citeulike-article-id:836713 TI - Chromatin Insulators. JF - Annu Rev Genet AD - Unit on Chromatin and Transcription, NICHD/NIH, Bethesda, MD 20892. SN - 0066-4197 N2 - Active and silenced chromatin domains are often in close juxtaposition to one another and enhancer and silencer elements operate over large distances to regulate the genes in these domains. The lack of promiscuity in the function of these elements suggests that active mechanisms exist to restrict their activity. Insulators are DNA elements that restrict the effects of long-range regulatory elements. Studies on different insulators from different organisms have identified common themes in their mode of action. Numerous insulators map to promoters of genes or have binding sites for transcription factors and like active chromatin hubs and silenced loci, insulators also cluster in the nucleus. These results bring into focus potential conserved mechanisms by which these elements might function in the nucleus. Expected online publication date for the Annual Review of Genetics Volume 40 is November 3, 2006. Please see http://www.annualreviews.org/catalog/pub_dates.asp for revised estimates. KW - chromatin KW - domains KW - insulators KW - review AU - Valenzuela, Lourdes AU - Kamakaka, Rohinton T PY - 2006/09/05/ UR - http://dx.doi.org/10.1146/annurev.genet.39.073003.113546 ER -