Adaptive evolution by optimizing expression levels in different environments

@article{citeulike:447087, abstract = {Organisms adapt to environmental changes through the fixation of mutations that enhance reproductive success. A recent study by Dekel and Alon demonstrated that Escherichia coli adapts to different growth conditions by fine-tuning protein levels, as predicted by a simple cost-benefit model. A study by Fong et al. showed that independent evolutionary trajectories lead to similar adaptive endpoints. Initial mutations on the path to adaptation altered the mRNA levels of numerous genes. Subsequent optimization through compensatory mutations restored the expression of most genes to baseline levels, except for a small set that retained differential levels of expression. These studies clarify how adaptation could occur by the alteration of gene expression.}, author = {Babu, Madan M. and Aravind, L. }, citeulike-article-id = {447087}, doi = {10.1016/j.tim.2005.11.005}, journal = {Trends in Microbiology}, keywords = {adaptive, bacteria, environment, evolution, expression, gene}, posted-at = {2006-03-21 20:00:58}, priority = {3}, title = {Adaptive evolution by optimizing expression levels in different environments}, url = {http://dx.doi.org/10.1016/j.tim.2005.11.005}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:447087 L3 - citeulike-article-id:447087 TI - Adaptive evolution by optimizing expression levels in different environments JF - Trends in Microbiology VL - In Press, Corrected Proof N2 - Organisms adapt to environmental changes through the fixation of mutations that enhance reproductive success. A recent study by Dekel and Alon demonstrated that Escherichia coli adapts to different growth conditions by fine-tuning protein levels, as predicted by a simple cost-benefit model. A study by Fong et al. showed that independent evolutionary trajectories lead to similar adaptive endpoints. Initial mutations on the path to adaptation altered the mRNA levels of numerous genes. Subsequent optimization through compensatory mutations restored the expression of most genes to baseline levels, except for a small set that retained differential levels of expression. These studies clarify how adaptation could occur by the alteration of gene expression. KW - adaptive KW - bacteria KW - environment KW - evolution KW - expression KW - gene AU - Babu, Madan AU - Aravind, L UR - http://dx.doi.org/10.1016/j.tim.2005.11.005 ER -