Draft genome of the filarial nematode parasite Brugia malayi.

by: E Ghedin, S Wang, D Spiro, E Caler, Q Zhao, J Crabtree, JE Allen, AL Delcher, DB Guiliano, D Miranda-Saavedra, SV Angiuoli, T Creasy, P Amedeo, B Haas, NM El-Sayed, JR Wortman, T Feldblyum, L Tallon, M Schatz, M Shumway, H Koo, SL Salzberg, S Schobel, M Pertea, M Pop, O White, GJ Barton, CK Carlow, MJ Crawford, J Daub, MW Dimmic, CF Estes, JM Foster, M Ganatra, WF Gregory, NM Johnson, J Jin, R Komuniecki, I Korf, S Kumar, S Laney, BW Li, W Li, TH Lindblom, S Lustigman, D Ma, CV Maina, DM Martin, JP McCarter, L McReynolds, M Mitreva, TB Nutman, J Parkinson, JM Peregrín-Alvarez, C Poole, Q Ren, L Saunders, AE Sluder, K Smith, M Stanke, TR Unnasch, J Ware, AD Wei, G Weil, DJ Williams, Y Zhang, SA Williams, C Fraser-Liggett, B Slatko, ML Blaxter, AL Scott

Science, Vol. 317, No. 5845. (21 September 2007), pp. 1756-1760.

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Abstract

Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during approximately 350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design.

@article{citeulike:1818059, abstract = {Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during approximately 350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design.}, address = {Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. GhedinE@dom.pitt.edu}, author = {Ghedin, E. and Wang, S. and Spiro, D. and Caler, E. and Zhao, Q. and Crabtree, J. and Allen, J. E. and Delcher, A. L. and Guiliano, D. B. and Miranda-Saavedra, D. and Angiuoli, S. V. and Creasy, T. and Amedeo, P. and Haas, B. and El-Sayed, N. M. and Wortman, J. R. and Feldblyum, T. and Tallon, L. and Schatz, M. and Shumway, M. and Koo, H. and Salzberg, S. L. and Schobel, S. and Pertea, M. and Pop, M. and White, O. and Barton, G. J. and Carlow, C. K. and Crawford, M. J. and Daub, J. and Dimmic, M. W. and Estes, C. F. and Foster, J. M. and Ganatra, M. and Gregory, W. F. and Johnson, N. M. and Jin, J. and Komuniecki, R. and Korf, I. and Kumar, S. and Laney, S. and Li, B. W. and Li, W. and Lindblom, T. H. and Lustigman, S. and Ma, D. and Maina, C. V. and Martin, D. M. and McCarter, J. P. and McReynolds, L. and Mitreva, M. and Nutman, T. B. and Parkinson, J. and Peregr\'{i}n-Alvarez, J. M. and Poole, C. and Ren, Q. and Saunders, L. and Sluder, A. E. and Smith, K. and Stanke, M. and Unnasch, T. R. and Ware, J. and Wei, A. D. and Weil, G. and Williams, D. J. and Zhang, Y. and Williams, S. A. and Fraser-Liggett, C. and Slatko, B. and Blaxter, M. L. and Scott, A. L. }, citeulike-article-id = {1818059}, doi = {10.1126/science.1145406}, issn = {1095-9203}, journal = {Science}, keywords = {genome\_sequence, nematode}, month = {September}, number = {5845}, pages = {1756--1760}, posted-at = {2007-10-25 02:18:35}, priority = {2}, title = {Draft genome of the filarial nematode parasite Brugia malayi.}, url = {http://dx.doi.org/10.1126/science.1145406}, volume = {317}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1818059 L3 - citeulike-article-id:1818059 TI - Draft genome of the filarial nematode parasite Brugia malayi. JF - Science VL - 317 IS - 5845 SP - 1756 EP - 1760 AD - Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. GhedinE@dom.pitt.edu SN - 1095-9203 N2 - Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during approximately 350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design. KW - genome_sequence KW - nematode AU - Ghedin, E AU - Wang, S AU - Spiro, D AU - Caler, E AU - Zhao, Q AU - Crabtree, J AU - Allen, JE AU - Delcher, AL AU - Guiliano, DB AU - Miranda-Saavedra, D AU - Angiuoli, SV AU - Creasy, T AU - Amedeo, P AU - Haas, B AU - El-Sayed, NM AU - Wortman, JR AU - Feldblyum, T AU - Tallon, L AU - Schatz, M AU - Shumway, M AU - Koo, H AU - Salzberg, SL AU - Schobel, S AU - Pertea, M AU - Pop, M AU - White, O AU - Barton, GJ AU - Carlow, CK AU - Crawford, MJ AU - Daub, J AU - Dimmic, MW AU - Estes, CF AU - Foster, JM AU - Ganatra, M AU - Gregory, WF AU - Johnson, NM AU - Jin, J AU - Komuniecki, R AU - Korf, I AU - Kumar, S AU - Laney, S AU - Li, BW AU - Li, W AU - Lindblom, TH AU - Lustigman, S AU - Ma, D AU - Maina, CV AU - Martin, DM AU - McCarter, JP AU - McReynolds, L AU - Mitreva, M AU - Nutman, TB AU - Parkinson, J AU - Peregrín-Alvarez, JM AU - Poole, C AU - Ren, Q AU - Saunders, L AU - Sluder, AE AU - Smith, K AU - Stanke, M AU - Unnasch, TR AU - Ware, J AU - Wei, AD AU - Weil, G AU - Williams, DJ AU - Zhang, Y AU - Williams, SA AU - Fraser-Liggett, C AU - Slatko, B AU - Blaxter, ML AU - Scott, AL PY - 2007/09/21/ UR - http://dx.doi.org/10.1126/science.1145406 ER -

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