Use of Chemometrics To Optimize the Operation of an Ion Source.

by: Natalie D Sousa, Christopher J Ellett, Michelle Gilbert, Andrew D Wright

Anal Chem (5 January 2008)

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DOI, American Chem. Soc. Publications, Pubmed, Hubmed

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Abstract

A chemometric approach has been used to optimize the Agilent multimode ion source. Initial factorial experimental design studies indicated that there was a significant degree of curvature in the experimental region, so further central composite design experiments were performed. Optimum conditions were found using statistical optimization tools, and these results were then validated. As a result, recommendations have been made for the value of each operational parameter in order to optimize response.

@article{citeulike:2218539, abstract = {A chemometric approach has been used to optimize the Agilent multimode ion source. Initial factorial experimental design studies indicated that there was a significant degree of curvature in the experimental region, so further central composite design experiments were performed. Optimum conditions were found using statistical optimization tools, and these results were then validated. As a result, recommendations have been made for the value of each operational parameter in order to optimize response.}, address = {AstraZeneca R\&D Charnwood, Bakewell Road, Loughborough, Leics, UK, LE11 5RH.}, author = {Sousa, Natalie D. and Ellett, Christopher J. and Gilbert, Michelle and Wright, Andrew D. }, citeulike-article-id = {2218539}, doi = {http://dx.doi.org/10.1021/ac701966r}, issn = {0003-2700}, journal = {Anal Chem}, keywords = {nuevo}, month = {January}, posted-at = {2008-01-11 10:38:36}, priority = {2}, title = {Use of Chemometrics To Optimize the Operation of an Ion Source.}, url = {http://dx.doi.org/10.1021/ac701966r}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2218539 L3 - citeulike-article-id:2218539 TI - Use of Chemometrics To Optimize the Operation of an Ion Source. JF - Anal Chem AD - AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics, UK, LE11 5RH. SN - 0003-2700 N2 - A chemometric approach has been used to optimize the Agilent multimode ion source. Initial factorial experimental design studies indicated that there was a significant degree of curvature in the experimental region, so further central composite design experiments were performed. Optimum conditions were found using statistical optimization tools, and these results were then validated. As a result, recommendations have been made for the value of each operational parameter in order to optimize response. KW - nuevo AU - Sousa, Natalie AU - Ellett, Christopher AU - Gilbert, Michelle AU - Wright, Andrew PY - 2008/01/05/ UR - http://dx.doi.org/10.1021/ac701966r ER -

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