Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial.

@article{citeulike:2954898, abstract = {CONTEXT: Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality. OBJECTIVE: To compare an established low-tidal-volume ventilation strategy with an experimental strategy based on the original "open-lung approach," combining low tidal volume, lung recruitment maneuvers, and high positive-end-expiratory pressure. DESIGN AND SETTING: Randomized controlled trial with concealed allocation and blinded data analysis conducted between August 2000 and March 2006 in 30 intensive care units in Canada, Australia, and Saudi Arabia. PATIENTS: Nine hundred eighty-three consecutive patients with acute lung injury and a ratio of arterial oxygen tension to inspired oxygen fraction not exceeding 250. INTERVENTIONS: The control strategy included target tidal volumes of 6 mL/kg of predicted body weight, plateau airway pressures not exceeding 30 cm H2O, and conventional levels of positive end-expiratory pressure (n = 508). The experimental strategy included target tidal volumes of 6 mL/kg of predicted body weight, plateau pressures not exceeding 40 cm H2O, recruitment maneuvers, and higher positive end-expiratory pressures (n = 475). MAIN OUTCOME MEASURE: All-cause hospital mortality. RESULTS: Eighty-five percent of the 983 study patients met criteria for acute respiratory distress syndrome at enrollment. Tidal volumes remained similar in the 2 groups, and mean positive end-expiratory pressures were 14.6 (SD, 3.4) cm H2O in the experimental group vs 9.8 (SD, 2.7) cm H2O among controls during the first 72 hours (P < .001). All-cause hospital mortality rates were 36.4\% and 40.4\%, respectively (relative risk [RR], 0.90; 95\% confidence interval [CI], 0.77-1.05; P = .19). Barotrauma rates were 11.2\% and 9.1\% (RR, 1.21; 95\% CI, 0.83-1.75; P = .33). The experimental group had lower rates of refractory hypoxemia (4.6\% vs 10.2\%; RR, 0.54; 95\% CI, 0.34-0.86; P = .01), death with refractory hypoxemia (4.2\% vs 8.9\%; RR, 0.56; 95\% CI, 0.34-0.93; P = .03), and previously defined eligible use of rescue therapies (5.1\% vs 9.3\%; RR, 0.61; 95\% CI, 0.38-0.99; P = .045). CONCLUSIONS: For patients with acute lung injury and acute respiratory distress syndrome, a multifaceted protocolized ventilation strategy designed to recruit and open the lung resulted in no significant difference in all-cause hospital mortality or barotrauma compared with an established low-tidal-volume protocolized ventilation strategy. This "open-lung" strategy did appear to improve secondary end points related to hypoxemia and use of rescue therapies. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00182195.}, address = {Department of Medicine, McMaster University, Hamilton, Ontario, Canada. meadema@hhsc.ca}, author = {Meade, M. O. and Cook, D. J. and Guyatt, G. H. and Slutsky, A. S. and Arabi, Y. M. and Cooper, D. J. and Davies, A. R. and Hand, L. E. and Zhou, Q. and Thabane, L. and Austin, P. and Lapinsky, S. and Baxter, A. and Russell, J. and Skrobik, Y. and Ronco, J. J. and Stewart, T. E. and }, citeulike-article-id = {2954898}, doi = {http://dx.doi.org/10.1001/jama.299.6.637}, issn = {1538-3598}, journal = {JAMA : the journal of the American Medical Association}, keywords = {icu}, month = {February}, number = {6}, pages = {637--645}, posted-at = {2008-07-03 04:44:01}, priority = {2}, title = {Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial.}, url = {http://dx.doi.org/10.1001/jama.299.6.637}, volume = {299}, year = {2008} }

TY - JOUR ID - citeulike:2954898 L3 - citeulike-article-id:2954898 TI - Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JF - JAMA : the journal of the American Medical Association VL - 299 IS - 6 SP - 637 EP - 645 AD - Department of Medicine, McMaster University, Hamilton, Ontario, Canada. meadema@hhsc.ca SN - 1538-3598 N2 - CONTEXT: Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality. OBJECTIVE: To compare an established low-tidal-volume ventilation strategy with an experimental strategy based on the original "open-lung approach," combining low tidal volume, lung recruitment maneuvers, and high positive-end-expiratory pressure. DESIGN AND SETTING: Randomized controlled trial with concealed allocation and blinded data analysis conducted between August 2000 and March 2006 in 30 intensive care units in Canada, Australia, and Saudi Arabia. PATIENTS: Nine hundred eighty-three consecutive patients with acute lung injury and a ratio of arterial oxygen tension to inspired oxygen fraction not exceeding 250. INTERVENTIONS: The control strategy included target tidal volumes of 6 mL/kg of predicted body weight, plateau airway pressures not exceeding 30 cm H2O, and conventional levels of positive end-expiratory pressure (n = 508). The experimental strategy included target tidal volumes of 6 mL/kg of predicted body weight, plateau pressures not exceeding 40 cm H2O, recruitment maneuvers, and higher positive end-expiratory pressures (n = 475). MAIN OUTCOME MEASURE: All-cause hospital mortality. RESULTS: Eighty-five percent of the 983 study patients met criteria for acute respiratory distress syndrome at enrollment. Tidal volumes remained similar in the 2 groups, and mean positive end-expiratory pressures were 14.6 (SD, 3.4) cm H2O in the experimental group vs 9.8 (SD, 2.7) cm H2O among controls during the first 72 hours (P < .001). All-cause hospital mortality rates were 36.4% and 40.4%, respectively (relative risk [RR], 0.90; 95% confidence interval [CI], 0.77-1.05; P = .19). Barotrauma rates were 11.2% and 9.1% (RR, 1.21; 95% CI, 0.83-1.75; P = .33). The experimental group had lower rates of refractory hypoxemia (4.6% vs 10.2%; RR, 0.54; 95% CI, 0.34-0.86; P = .01), death with refractory hypoxemia (4.2% vs 8.9%; RR, 0.56; 95% CI, 0.34-0.93; P = .03), and previously defined eligible use of rescue therapies (5.1% vs 9.3%; RR, 0.61; 95% CI, 0.38-0.99; P = .045). CONCLUSIONS: For patients with acute lung injury and acute respiratory distress syndrome, a multifaceted protocolized ventilation strategy designed to recruit and open the lung resulted in no significant difference in all-cause hospital mortality or barotrauma compared with an established low-tidal-volume protocolized ventilation strategy. This "open-lung" strategy did appear to improve secondary end points related to hypoxemia and use of rescue therapies. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00182195. KW - icu AU - Meade, MO AU - Cook, DJ AU - Guyatt, GH AU - Slutsky, AS AU - Arabi, YM AU - Cooper, DJ AU - Davies, AR AU - Hand, LE AU - Zhou, Q AU - Thabane, L AU - Austin, P AU - Lapinsky, S AU - Baxter, A AU - Russell, J AU - Skrobik, Y AU - Ronco, JJ AU - Stewart, TE PY - 2008/02/13/ UR - http://dx.doi.org/10.1001/jama.299.6.637 ER -