Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

@article{citeulike:2903081, abstract = {Dietary carbohydrates regulate hepatic lipogenesis by controlling the expression of critical enzymes in glycolytic and lipogenic pathways. We found that the transcription factor XBP1, a key regulator of the unfolded protein response, is required for the unrelated function of normal fatty acid synthesis in the liver. XBP1 protein expression in mice was elevated after feeding carbohydrates and corresponded with the induction of critical genes involved in fatty acid synthesis. Inducible, selective deletion of XBP1 in the liver resulted in marked hypocholesterolemia and hypotriglyceridemia, secondary to a decreased production of lipids from the liver. This phenotype was not accompanied by hepatic steatosis or compromise in protein secretory function. The identification of XBP1 as a regulator of lipogenesis has important implications for human dyslipidemias. 10.1126/science.1158042}, author = {Lee, Ann-Hwee and Scapa, Erez F. and Cohen, David E. and Glimcher, Laurie H. }, citeulike-article-id = {2903081}, doi = {10.1126/science.1158042}, journal = {Science}, keywords = {carbohydrates, diet, fat, fatty, glycolytic, lipids, lipogenic, liver}, month = {June}, number = {5882}, pages = {1492--1496}, posted-at = {2008-06-17 20:49:01}, priority = {2}, title = {Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1}, url = {http://dx.doi.org/10.1126/science.1158042}, volume = {320}, year = {2008} }

TY - JOUR ID - citeulike:2903081 L3 - citeulike-article-id:2903081 TI - Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1 JF - Science VL - 320 IS - 5882 SP - 1492 EP - 1496 N2 - Dietary carbohydrates regulate hepatic lipogenesis by controlling the expression of critical enzymes in glycolytic and lipogenic pathways. We found that the transcription factor XBP1, a key regulator of the unfolded protein response, is required for the unrelated function of normal fatty acid synthesis in the liver. XBP1 protein expression in mice was elevated after feeding carbohydrates and corresponded with the induction of critical genes involved in fatty acid synthesis. Inducible, selective deletion of XBP1 in the liver resulted in marked hypocholesterolemia and hypotriglyceridemia, secondary to a decreased production of lipids from the liver. This phenotype was not accompanied by hepatic steatosis or compromise in protein secretory function. The identification of XBP1 as a regulator of lipogenesis has important implications for human dyslipidemias. 10.1126/science.1158042 KW - carbohydrates KW - diet KW - fat KW - fatty KW - glycolytic KW - lipids KW - lipogenic KW - liver AU - Lee, Ann-Hwee AU - Scapa, Erez AU - Cohen, David AU - Glimcher, Laurie PY - 2008/06/13/ UR - http://dx.doi.org/10.1126/science.1158042 ER -