Transposable element fragments in protein-coding regions and their contributions to human functional proteins

by: Ming Wu, Li Li, Zhirong Sun

Gene, Vol. 401, No. 1-2. (15 October 2007), pp. 165-171.

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Abstract

Transposable elements (TEs) and their contributions to protein-coding regions are of particular interest. Here we searched for TE fragments in Homo sapiens at both the transcript and protein levels. We found evidence in support of TE exonization and its association with alternative splicing. Despite recent findings that long evolutionary times are required to incorporate TE into proteins, we found many functional proteins with translated TE cassettes derived from young TEs. Analyses of two Bcl-family proteins and Alu-encoded segments suggest the coding and functional potential of TE sequences.

@article{citeulike:1622722, abstract = {Transposable elements (TEs) and their contributions to protein-coding regions are of particular interest. Here we searched for TE fragments in Homo sapiens at both the transcript and protein levels. We found evidence in support of TE exonization and its association with alternative splicing. Despite recent findings that long evolutionary times are required to incorporate TE into proteins, we found many functional proteins with translated TE cassettes derived from young TEs. Analyses of two Bcl-family proteins and Alu-encoded segments suggest the coding and functional potential of TE sequences.}, author = {Wu, Ming and Li, Li and Sun, Zhirong }, citeulike-article-id = {1622722}, doi = {10.1016/j.gene.2007.07.012}, journal = {Gene}, keywords = {mammals, transposon}, month = {October}, number = {1-2}, pages = {165--171}, posted-at = {2008-04-26 19:51:20}, priority = {2}, title = {Transposable element fragments in protein-coding regions and their contributions to human functional proteins}, url = {http://dx.doi.org/10.1016/j.gene.2007.07.012}, volume = {401}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1622722 L3 - citeulike-article-id:1622722 TI - Transposable element fragments in protein-coding regions and their contributions to human functional proteins JF - Gene VL - 401 IS - 1-2 SP - 165 EP - 171 N2 - Transposable elements (TEs) and their contributions to protein-coding regions are of particular interest. Here we searched for TE fragments in Homo sapiens at both the transcript and protein levels. We found evidence in support of TE exonization and its association with alternative splicing. Despite recent findings that long evolutionary times are required to incorporate TE into proteins, we found many functional proteins with translated TE cassettes derived from young TEs. Analyses of two Bcl-family proteins and Alu-encoded segments suggest the coding and functional potential of TE sequences. KW - mammals KW - transposon AU - Wu, Ming AU - Li, Li AU - Sun, Zhirong PY - 2007/10/15/ UR - http://dx.doi.org/10.1016/j.gene.2007.07.012 ER -

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