The Role of Regulatory Genes During Maize Domestication: Evidence From Nucleotide Polymorphism and Gene Expression

@article{citeulike:2721771, abstract = {We investigated DNA sequence variation in 72 candidate genes in maize landraces and the wild ancestor of maize, teosinte. The candidate genes were chosen because they exhibit very low sequence diversity among maize inbreds and have sequence homology to known regulatory genes. We observed signatures of selection in 17 candidate genes, indicating that they were potential targets of artificial selection during domestication. In addition, 21 candidate genes were identified as potential targets of natural selection in teosinte. A comparison of the proportion of selected genes between our regulatory genes and genes unfiltered for their potential function (but also with very low sequence diversity among maize inbreds) provided some weak evidence that regulatory genes are overrepresented among selected genes. We detected no significant association between the positions of genes identified as potential targets of selection during domestication and quantitative trait loci (QTL) responsible for maize domestication traits. However, a subset of these genes, those identified by sequence homology as kinase/phosphatase genes, significantly cluster with the domestication QTL. We also analyzed expression profiles of genes in distinct maize tissues and observed that domestication genes are expressed on average at a significantly higher level than neutral genes in reproductive organs, including kernels. 10.1534/genetics.107.085506}, author = {Zhao, Qiong and Thuillet, Anne-Celine and Uhlmann, Nathan K. and Weber, Allison and Rafalski, Antoni J. and Allen, Stephen M. and Tingey, Scott and Doebley, John }, citeulike-article-id = {2721771}, doi = {10.1534/genetics.107.085506}, journal = {Genetics}, keywords = {cisreg, maize, polymorphism}, month = {April}, number = {4}, pages = {2133--2143}, posted-at = {2008-04-26 14:27:05}, priority = {2}, title = {The Role of Regulatory Genes During Maize Domestication: Evidence From Nucleotide Polymorphism and Gene Expression}, url = {http://dx.doi.org/10.1534/genetics.107.085506}, volume = {178}, year = {2008} }

TY - JOUR ID - citeulike:2721771 L3 - citeulike-article-id:2721771 TI - The Role of Regulatory Genes During Maize Domestication: Evidence From Nucleotide Polymorphism and Gene Expression JF - Genetics VL - 178 IS - 4 SP - 2133 EP - 2143 N2 - We investigated DNA sequence variation in 72 candidate genes in maize landraces and the wild ancestor of maize, teosinte. The candidate genes were chosen because they exhibit very low sequence diversity among maize inbreds and have sequence homology to known regulatory genes. We observed signatures of selection in 17 candidate genes, indicating that they were potential targets of artificial selection during domestication. In addition, 21 candidate genes were identified as potential targets of natural selection in teosinte. A comparison of the proportion of selected genes between our regulatory genes and genes unfiltered for their potential function (but also with very low sequence diversity among maize inbreds) provided some weak evidence that regulatory genes are overrepresented among selected genes. We detected no significant association between the positions of genes identified as potential targets of selection during domestication and quantitative trait loci (QTL) responsible for maize domestication traits. However, a subset of these genes, those identified by sequence homology as kinase/phosphatase genes, significantly cluster with the domestication QTL. We also analyzed expression profiles of genes in distinct maize tissues and observed that domestication genes are expressed on average at a significantly higher level than neutral genes in reproductive organs, including kernels. 10.1534/genetics.107.085506 KW - cisreg KW - maize KW - polymorphism AU - Zhao, Qiong AU - Thuillet, Anne-Celine AU - Uhlmann, Nathan AU - Weber, Allison AU - Rafalski, Antoni AU - Allen, Stephen AU - Tingey, Scott AU - Doebley, John PY - 2008/04/01/ UR - http://dx.doi.org/10.1534/genetics.107.085506 ER -