Functional genomics and proteomics as a foundation for systems biology.

@article{citeulike:387443, abstract = {Developments in high-throughput measurement technologies for biological molecules have created a paradigm shift in modern life science research. The field of systems biology attempts to provide a systems-level understanding by systematically organising the genomic, functional genomic and proteomic data obtained from genetic and environmental perturbations of interest and using the data to build a descriptive and mechanistic model of the biological phenomena. The goal is to build a mathematical framework with some predictive abilities. This review highlights the need for system-level understanding, lists some of the high-throughput measurement tools of importance in systems biology, reviews various types of experimental and computational approaches being used in systems biology research and attempts to address some of the challenges facing this research community.}, address = {Scool of Chemical and Biomolecular Engineering at Cornell University, USA.}, author = {Aggarwal, K. and Lee, K. H. }, citeulike-article-id = {387443}, doi = {http://dx.doi.org/10.1093/bfgp/2.3.175}, issn = {1473-9550}, journal = {Brief Funct Genomic Proteomic}, keywords = {functional, genomics}, month = {October}, number = {3}, pages = {175--184}, posted-at = {2007-04-28 13:20:23}, priority = {3}, title = {Functional genomics and proteomics as a foundation for systems biology.}, url = {http://dx.doi.org/10.1093/bfgp/2.3.175}, volume = {2}, year = {2003} }

TY - JOUR ID - citeulike:387443 L3 - citeulike-article-id:387443 N2 - Developments in high-throughput measurement technologies for biological molecules have created a paradigm shift in modern life science research. The field of systems biology attempts to provide a systems-level understanding by systematically organising the genomic, functional genomic and proteomic data obtained from genetic and environmental perturbations of interest and using the data to build a descriptive and mechanistic model of the biological phenomena. The goal is to build a mathematical framework with some predictive abilities. This review highlights the need for system-level understanding, lists some of the high-throughput measurement tools of importance in systems biology, reviews various types of experimental and computational approaches being used in systems biology research and attempts to address some of the challenges facing this research community. IS - 3 JF - Brief Funct Genomic Proteomic SN - 1473-9550 AD - Scool of Chemical and Biomolecular Engineering at Cornell University, USA. EP - 184 TI - Functional genomics and proteomics as a foundation for systems biology. VL - 2 SP - 175 KW - functional KW - genomics AU - Aggarwal, K AU - Lee, KH PY - 2003/10// UR - http://dx.doi.org/10.1093/bfgp/2.3.175 ER -