A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons.

@article{citeulike:1612445, abstract = {MicroRNAs (miRNAs) are evolutionarily conserved, 18- to 25-nucleotide, non-protein coding transcripts that posttranscriptionally regulate gene expression during development. miRNAs also occur in postmitotic cells, such as neurons in the mammalian central nervous system, but their function is less well characterized. We investigated the role of miRNAs in mammalian midbrain dopaminergic neurons (DNs). We identified a miRNA, miR-133b, that is specifically expressed in midbrain DNs and is deficient in midbrain tissue from patients with Parkinson's disease. miR-133b regulates the maturation and function of midbrain DNs within a negative feedback circuit that includes the paired-like homeodomain transcription factor Pitx3. We propose a role for this feedback circuit in the fine-tuning of dopaminergic behaviors such as locomotion.}, address = {Departments of Pathology and Neurology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons 15-403, 630 West 168th Street, New York, NY 10032, USA.}, author = {Kim, J. and Inoue, K. and Ishii, J. and Vanti, W. B. and Voronov, S. V. and Murchison, E. and Hannon, G. and Abeliovich, A. }, citeulike-article-id = {1612445}, doi = {http://dx.doi.org/10.1126/science.1140481}, issn = {1095-9203}, journal = {Science}, keywords = {microrna, neurodegeneration}, month = {August}, number = {5842}, pages = {1220--1224}, posted-at = {2008-03-13 21:21:25}, priority = {2}, title = {A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons.}, url = {http://dx.doi.org/10.1126/science.1140481}, volume = {317}, year = {2007} }

TY - JOUR ID - citeulike:1612445 L3 - citeulike-article-id:1612445 N2 - MicroRNAs (miRNAs) are evolutionarily conserved, 18- to 25-nucleotide, non-protein coding transcripts that posttranscriptionally regulate gene expression during development. miRNAs also occur in postmitotic cells, such as neurons in the mammalian central nervous system, but their function is less well characterized. We investigated the role of miRNAs in mammalian midbrain dopaminergic neurons (DNs). We identified a miRNA, miR-133b, that is specifically expressed in midbrain DNs and is deficient in midbrain tissue from patients with Parkinson's disease. miR-133b regulates the maturation and function of midbrain DNs within a negative feedback circuit that includes the paired-like homeodomain transcription factor Pitx3. We propose a role for this feedback circuit in the fine-tuning of dopaminergic behaviors such as locomotion. IS - 5842 JF - Science SN - 1095-9203 AD - Departments of Pathology and Neurology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons 15-403, 630 West 168th Street, New York, NY 10032, USA. EP - 1224 TI - A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons. VL - 317 SP - 1220 KW - microrna KW - neurodegeneration AU - Kim, J AU - Inoue, K AU - Ishii, J AU - Vanti, WB AU - Voronov, SV AU - Murchison, E AU - Hannon, G AU - Abeliovich, A PY - 2007/08/31/ UR - http://dx.doi.org/10.1126/science.1140481 ER -