Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons

@article{citeulike:2773667, abstract = {Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change. 10.1126/science.1156093}, author = {Prahlad, Veena and Cornelius, Tyler and Morimoto, Richard I. }, citeulike-article-id = {2773667}, doi = {10.1126/science.1156093}, journal = {Science}, keywords = {c\_elegans, dauer, environmental\_sensing, heat\_shock, neuron, population\_density\_response, signal\_integration}, month = {May}, number = {5877}, pages = {811--814}, posted-at = {2008-05-08 22:57:18}, priority = {2}, title = {Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons}, url = {http://dx.doi.org/10.1126/science.1156093}, volume = {320}, year = {2008} }

TY - JOUR ID - citeulike:2773667 L3 - citeulike-article-id:2773667 TI - Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons JF - Science VL - 320 IS - 5877 SP - 811 EP - 814 N2 - Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change. 10.1126/science.1156093 KW - c_elegans KW - dauer KW - environmental_sensing KW - heat_shock KW - neuron KW - population_density_response KW - signal_integration AU - Prahlad, Veena AU - Cornelius, Tyler AU - Morimoto, Richard PY - 2008/05/09/ UR - http://dx.doi.org/10.1126/science.1156093 ER -