Issues and strategies in the DNA identification of World Trade Center victims.

by: CH Brenner, BS Weir

Theor Popul Biol, Vol. 63, No. 3. (May 2003), pp. 173-178.

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Abstract

Identification of the nearly 3000 victims of the World Trade Center attack, represented by about 15,000 body parts, rests heavily on DNA. Reference DNA profiles are often from relatives rather than from the deceased themselves. With so large a set of victims, coincidental similarities between non-relatives abound. Therefore considerable care is necessary to succeed in correlating references with correct victims while avoiding spurious assignments. Typically multiple relatives are necessary to establish the identity of a victim. We describe a 3-stage paradigm--collapse, screen, test--to organize the work of sorting out the identities. Inter alia we present a simple and general formula for the likelihood ratio governing practically any potential relationship between two DNA profiles.

@article{citeulike:519742, abstract = {Identification of the nearly 3000 victims of the World Trade Center attack, represented by about 15,000 body parts, rests heavily on DNA. Reference DNA profiles are often from relatives rather than from the deceased themselves. With so large a set of victims, coincidental similarities between non-relatives abound. Therefore considerable care is necessary to succeed in correlating references with correct victims while avoiding spurious assignments. Typically multiple relatives are necessary to establish the identity of a victim. We describe a 3-stage paradigm--collapse, screen, test--to organize the work of sorting out the identities. Inter alia we present a simple and general formula for the likelihood ratio governing practically any potential relationship between two DNA profiles.}, address = {Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, NC 27695-7566, USA. chb@dna-view.com}, author = {Brenner, C. H. and Weir, B. S. }, citeulike-article-id = {519742}, issn = {0040-5809}, journal = {Theor Popul Biol}, keywords = {911}, month = {May}, number = {3}, pages = {173--178}, posted-at = {2008-01-19 19:22:10}, priority = {2}, title = {Issues and strategies in the DNA identification of World Trade Center victims.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12689789}, volume = {63}, year = {2003} }

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TY - JOUR ID - citeulike:519742 L3 - citeulike-article-id:519742 TI - Issues and strategies in the DNA identification of World Trade Center victims. JF - Theor Popul Biol VL - 63 IS - 3 SP - 173 EP - 178 AD - Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, NC 27695-7566, USA. chb@dna-view.com SN - 0040-5809 N2 - Identification of the nearly 3000 victims of the World Trade Center attack, represented by about 15,000 body parts, rests heavily on DNA. Reference DNA profiles are often from relatives rather than from the deceased themselves. With so large a set of victims, coincidental similarities between non-relatives abound. Therefore considerable care is necessary to succeed in correlating references with correct victims while avoiding spurious assignments. Typically multiple relatives are necessary to establish the identity of a victim. We describe a 3-stage paradigm--collapse, screen, test--to organize the work of sorting out the identities. Inter alia we present a simple and general formula for the likelihood ratio governing practically any potential relationship between two DNA profiles. KW - 911 AU - Brenner, CH AU - Weir, BS PY - 2003/05// UR - http://view.ncbi.nlm.nih.gov/pubmed/12689789 ER -

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