Dynamics and interplay of nuclear architecture, genome organization, and gene expression.

@article{citeulike:2086234, abstract = {The organization of the genome in the nucleus of a eukaryotic cell is fairly complex and dynamic. Various features of the nuclear architecture, including compartmentalization of molecular machines and the spatial arrangement of genomic sequences, help to carry out and regulate nuclear processes, such as DNA replication, DNA repair, gene transcription, RNA processing, and mRNA transport. Compartmentalized multiprotein complexes undergo extensive modifications or exchange of protein subunits, allowing for an exquisite dynamics of structural components and functional processes of the nucleus. The architecture of the interphase nucleus is linked to the spatial arrangement of genes and gene clusters, the structure of chromatin, and the accessibility of regulatory DNA elements. In this review, we discuss recent studies that have provided exciting insight into the interplay between nuclear architecture, genome organization, and gene expression.}, address = {Max Planck Institute of Immunobiology, 79108 Freiburg, Germany.}, author = {Schneider, R. and Grosschedl, R. }, citeulike-article-id = {2086234}, doi = {10.1101/gad.1604607}, issn = {0890-9369}, journal = {Genes Dev}, keywords = {gene\_expression, genome\_organization, nuclear\_architecture, transcription}, month = {December}, number = {23}, pages = {3027--3043}, posted-at = {2007-12-10 16:47:29}, priority = {5}, title = {Dynamics and interplay of nuclear architecture, genome organization, and gene expression.}, url = {http://dx.doi.org/10.1101/gad.1604607}, volume = {21}, year = {2007} }

TY - JOUR ID - citeulike:2086234 L3 - citeulike-article-id:2086234 TI - Dynamics and interplay of nuclear architecture, genome organization, and gene expression. JF - Genes Dev VL - 21 IS - 23 SP - 3027 EP - 3043 AD - Max Planck Institute of Immunobiology, 79108 Freiburg, Germany. SN - 0890-9369 N2 - The organization of the genome in the nucleus of a eukaryotic cell is fairly complex and dynamic. Various features of the nuclear architecture, including compartmentalization of molecular machines and the spatial arrangement of genomic sequences, help to carry out and regulate nuclear processes, such as DNA replication, DNA repair, gene transcription, RNA processing, and mRNA transport. Compartmentalized multiprotein complexes undergo extensive modifications or exchange of protein subunits, allowing for an exquisite dynamics of structural components and functional processes of the nucleus. The architecture of the interphase nucleus is linked to the spatial arrangement of genes and gene clusters, the structure of chromatin, and the accessibility of regulatory DNA elements. In this review, we discuss recent studies that have provided exciting insight into the interplay between nuclear architecture, genome organization, and gene expression. KW - gene_expression KW - genome_organization KW - nuclear_architecture KW - transcription AU - Schneider, R AU - Grosschedl, R PY - 2007/12/01/ UR - http://dx.doi.org/10.1101/gad.1604607 ER -