Surgery and Risk of Sporadic Creutzfeldt-Jakob Disease in Denmark and Sweden: Registry-Based Case-Control Studies.

@article{citeulike:3397216, abstract = {Background: Epidemiologic evidence of surgical transmission of sporadic Creutzfeldt-Jakob disease (sCJD) remains controversial. Methods: From Danish and Swedish registries we selected 167 definite and probable sCJD cases (with onset between 1987 and 2003) and 3,059 controls (835 age-, sex-, and residence-matched, and 2,224 unmatched). Independent of case/control status, surgical histories were obtained from National Hospital Discharge Registries. Surgical procedures were categorized by body system group and lag time to onset of sCJD. Exposure frequencies were compared using logistic regression. Results: A history of any major surgery, conducted >/=20 years before sCJD onset, was more common in cases than both matched (OR = 2.44, 95\% CI = 1.46-4.07) and unmatched controls (OR = 2.25, 95\% CI = 1.48-3.44). This observation was corroborated by a linear increase in risk per surgical discharge (OR = 1.57, 95\% CI = 1.13-2.18; OR = 1.50, 95\% CI = 1.18-1.91). Surgery of various body systems, including peripheral vessels, digestive system and spleen, and female genital organs, was significantly associated with increased sCJD risk. Conclusions: A variety of major surgical procedures constitute a risk factor for sCJD following an incubation period of many years. A considerable number of sCJD cases may originate from health care-related accidental transmission.}, author = {Mahillo-Fernandez, Ignacio and de Pedro-Cuesta, Jes\'{u}s and Bleda, Maria Jos\'{e} J. and Cruz, Mabel and Mølbak, K\r{a}re and Laursen, Henning and Falkenhorst, Gerhard and Mart\'{i}nez-Mart\'{i}n, Pablo and Siden, Ake }, citeulike-article-id = {3397216}, doi = {http://dx.doi.org/10.1159/000163097}, issn = {1423-0208}, journal = {Neuroepidemiology}, keywords = {icjd, prion, risk, surgery}, month = {October}, number = {4}, pages = {229--240}, posted-at = {2008-10-12 04:00:12}, priority = {5}, title = {Surgery and Risk of Sporadic Creutzfeldt-Jakob Disease in Denmark and Sweden: Registry-Based Case-Control Studies.}, url = {http://dx.doi.org/10.1159/000163097}, volume = {31}, year = {2008} }

TY - JOUR ID - citeulike:3397216 L3 - citeulike-article-id:3397216 N2 - Background: Epidemiologic evidence of surgical transmission of sporadic Creutzfeldt-Jakob disease (sCJD) remains controversial. Methods: From Danish and Swedish registries we selected 167 definite and probable sCJD cases (with onset between 1987 and 2003) and 3,059 controls (835 age-, sex-, and residence-matched, and 2,224 unmatched). Independent of case/control status, surgical histories were obtained from National Hospital Discharge Registries. Surgical procedures were categorized by body system group and lag time to onset of sCJD. Exposure frequencies were compared using logistic regression. Results: A history of any major surgery, conducted >/=20 years before sCJD onset, was more common in cases than both matched (OR = 2.44, 95% CI = 1.46-4.07) and unmatched controls (OR = 2.25, 95% CI = 1.48-3.44). This observation was corroborated by a linear increase in risk per surgical discharge (OR = 1.57, 95% CI = 1.13-2.18; OR = 1.50, 95% CI = 1.18-1.91). Surgery of various body systems, including peripheral vessels, digestive system and spleen, and female genital organs, was significantly associated with increased sCJD risk. Conclusions: A variety of major surgical procedures constitute a risk factor for sCJD following an incubation period of many years. A considerable number of sCJD cases may originate from health care-related accidental transmission. IS - 4 JF - Neuroepidemiology SN - 1423-0208 EP - 240 TI - Surgery and Risk of Sporadic Creutzfeldt-Jakob Disease in Denmark and Sweden: Registry-Based Case-Control Studies. VL - 31 SP - 229 KW - icjd KW - prion KW - risk KW - surgery AU - Mahillo-Fernandez, Ignacio AU - de Pedro-Cuesta, Jesús AU - Bleda, Maria José AU - Cruz, Mabel AU - Mølbak, Kåre AU - Laursen, Henning AU - Falkenhorst, Gerhard AU - Martínez-Martín, Pablo AU - Siden, Ake PY - 2008/10/09/ UR - http://dx.doi.org/10.1159/000163097 ER -