Neurostimulatory therapeutics in management of treatment-resistant depression with focus on deep brain stimulation.

@article{citeulike:3134619, abstract = {Treatment-resistant depression continues to pose a major medical challenge, as up to one-third of patients with major depressive disorder fail to have an adequate response to standard pharmacotherapies. An improved understanding of the complex circuitry underlying depressive disorders has fostered an explosion in the development of new, nonpharmacological approaches. Each of these treatments seeks to restore normal brain activity via electrical or magnetic stimulation. In this article, the authors discuss the ongoing evolution of neurostimulatory treatments for treatment-resistant depression, reviewing the methods, efficacy, and current research on electroconvulsive therapy, repetitive transcranial magnetic stimulation, magnetic seizure therapy, focal electrically administered stimulated seizure therapy, transcranial direct current stimulation, chronic epidural cortical stimulation, and vagus nerve stimulation. Special attention is given to deep brain stimulation, the most focally targeted approach. The history, purported mechanisms of action, and current research are outlined in detail. Although deep brain stimulation is the most invasive of the neurostimulatory treatments developed to date, it may hold significant promise in alleviating symptoms and improving the quality of life for patients with the most severe and disabling mood disorders. Mt Sinai J Med 75:263-275, 2008. (c) 2008 Mount Sinai School of Medicine.}, address = {Department of Neuroscience, Mount Sinai School of Medicine, New York, NY.}, author = {Dumitriu, Dani and Collins, Kate and Alterman, Ron and Mathew, Sanjay J J. }, citeulike-article-id = {3134619}, doi = {http://dx.doi.org/10.1002/msj.20044}, issn = {1931-7581}, journal = {The Mount Sinai journal of medicine, New York}, keywords = {dbs, depression, neurostimulation}, month = {August}, number = {3}, pages = {263--275}, posted-at = {2008-08-19 01:51:24}, priority = {2}, title = {Neurostimulatory therapeutics in management of treatment-resistant depression with focus on deep brain stimulation.}, url = {http://dx.doi.org/10.1002/msj.20044}, volume = {75}, year = {2008} }

TY - JOUR ID - citeulike:3134619 L3 - citeulike-article-id:3134619 N2 - Treatment-resistant depression continues to pose a major medical challenge, as up to one-third of patients with major depressive disorder fail to have an adequate response to standard pharmacotherapies. An improved understanding of the complex circuitry underlying depressive disorders has fostered an explosion in the development of new, nonpharmacological approaches. Each of these treatments seeks to restore normal brain activity via electrical or magnetic stimulation. In this article, the authors discuss the ongoing evolution of neurostimulatory treatments for treatment-resistant depression, reviewing the methods, efficacy, and current research on electroconvulsive therapy, repetitive transcranial magnetic stimulation, magnetic seizure therapy, focal electrically administered stimulated seizure therapy, transcranial direct current stimulation, chronic epidural cortical stimulation, and vagus nerve stimulation. Special attention is given to deep brain stimulation, the most focally targeted approach. The history, purported mechanisms of action, and current research are outlined in detail. Although deep brain stimulation is the most invasive of the neurostimulatory treatments developed to date, it may hold significant promise in alleviating symptoms and improving the quality of life for patients with the most severe and disabling mood disorders. Mt Sinai J Med 75:263-275, 2008. (c) 2008 Mount Sinai School of Medicine. IS - 3 JF - The Mount Sinai journal of medicine, New York SN - 1931-7581 AD - Department of Neuroscience, Mount Sinai School of Medicine, New York, NY. EP - 275 TI - Neurostimulatory therapeutics in management of treatment-resistant depression with focus on deep brain stimulation. VL - 75 SP - 263 KW - dbs KW - depression KW - neurostimulation AU - Dumitriu, Dani AU - Collins, Kate AU - Alterman, Ron AU - Mathew, Sanjay J PY - 2008/08/14/ UR - http://dx.doi.org/10.1002/msj.20044 ER -