Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation.

by: K Doh-Ura, T Iwaki, B Caughey

Journal of virology, Vol. 74, No. 10. (May 2000), pp. 4894-4897.

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Abstract

We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein.

@article{citeulike:3129179, abstract = {We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein.}, address = {Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. doh-ura@np.med.kyushu-u.ac.jp}, author = {Doh-Ura, K. and Iwaki, T. and Caughey, B. }, citeulike-article-id = {3129179}, issn = {0022-538X}, journal = {Journal of virology}, keywords = {prion\_diseases, therapy}, month = {May}, number = {10}, pages = {4894--4897}, posted-at = {2008-08-17 00:18:51}, priority = {5}, title = {Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10775631}, volume = {74}, year = {2000} }

RIS record

TY - JOUR ID - citeulike:3129179 L3 - citeulike-article-id:3129179 N2 - We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein. IS - 10 JF - Journal of virology SN - 0022-538X AD - Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. doh-ura@np.med.kyushu-u.ac.jp EP - 4897 TI - Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. VL - 74 SP - 4894 KW - prion_diseases KW - therapy AU - Doh-Ura, K AU - Iwaki, T AU - Caughey, B PY - 2000/05// UR - http://view.ncbi.nlm.nih.gov/pubmed/10775631 ER -

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