CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease.

@article{citeulike:2575623, abstract = {OBJECTIVES: To analyze the diagnostic sensitivity and specificity of various brain-derived proteins (14-3-3, Tau, neuron specific enolase [NSE], and S100b) in the CSF of patients with Creutzfeldt-Jakob disease (CJD) and to analyze biologic factors that modify these parameters. METHODS: CSF was tested for 14-3-3, Tau, NSE, and S100b in 1,859 patients with sporadic, genetic, iatrogenic, and variant CJD, and in 1,117 controls. RESULTS: The highest sensitivity was achieved for 14-3-3 and Tau in sporadic CJD (85\% and 86\%), and a combined determination of 14-3-3 and Tau, S100b, or NSE increased the sensitivity to over 93\%. A multivariate analysis showed that the sensitivity of all tests was highest in patients with the shortest disease duration, age at onset >40 years, and homozygosity at codon 129 of the prion protein gene. In a group of patients with repeated lumbar punctures, a second test also increased the diagnostic sensitivity. CONCLUSIONS: The detection of elevated levels of brain-derived proteins in the CSF in patients with suspected Creutzfeldt-Jakob disease is a valuable diagnostic test. A second lumbar puncture may be of value in patients with atypical clinical course in whom the first test was negative.}, address = {Department of Epidemiology \&s Biostatistics, Erasmus University Medical Center Rotterdam, The Netherlands.}, author = {Sanchez-Juan, P. and Green, A. and Ladogana, A. and Cuadrado-Corrales, N. and S\'{a}anchez-Valle, R. and Mitrov\'{a}a, E. and Stoeck, K. and Sklaviadis, T. and Kulczycki, J. and Hess, K. and Bodemer, M. and Slivarichov\'{a}, D. and Saiz, A. and Calero, M. and Ingrosso, L. and Knight, R. and Janssens, A. C. and van Duijn, C. M. and Zerr, I. }, citeulike-article-id = {2575623}, doi = {http://dx.doi.org/10.1212/01.wnl.0000230159.67128.00}, issn = {1526-632X}, journal = {Neurology}, keywords = {cjd, csf}, month = {August}, number = {4}, pages = {637--643}, posted-at = {2008-03-24 01:50:11}, priority = {5}, title = {CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease.}, url = {http://dx.doi.org/10.1212/01.wnl.0000230159.67128.00}, volume = {67}, year = {2006} }

TY - JOUR ID - citeulike:2575623 L3 - citeulike-article-id:2575623 N2 - OBJECTIVES: To analyze the diagnostic sensitivity and specificity of various brain-derived proteins (14-3-3, Tau, neuron specific enolase [NSE], and S100b) in the CSF of patients with Creutzfeldt-Jakob disease (CJD) and to analyze biologic factors that modify these parameters. METHODS: CSF was tested for 14-3-3, Tau, NSE, and S100b in 1,859 patients with sporadic, genetic, iatrogenic, and variant CJD, and in 1,117 controls. RESULTS: The highest sensitivity was achieved for 14-3-3 and Tau in sporadic CJD (85% and 86%), and a combined determination of 14-3-3 and Tau, S100b, or NSE increased the sensitivity to over 93%. A multivariate analysis showed that the sensitivity of all tests was highest in patients with the shortest disease duration, age at onset >40 years, and homozygosity at codon 129 of the prion protein gene. In a group of patients with repeated lumbar punctures, a second test also increased the diagnostic sensitivity. CONCLUSIONS: The detection of elevated levels of brain-derived proteins in the CSF in patients with suspected Creutzfeldt-Jakob disease is a valuable diagnostic test. A second lumbar puncture may be of value in patients with atypical clinical course in whom the first test was negative. IS - 4 JF - Neurology SN - 1526-632X AD - Department of Epidemiology &s Biostatistics, Erasmus University Medical Center Rotterdam, The Netherlands. EP - 643 TI - CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease. VL - 67 SP - 637 KW - cjd KW - csf AU - Sanchez-Juan, P AU - Green, A AU - Ladogana, A AU - Cuadrado-Corrales, N AU - Sáanchez-Valle, R AU - Mitrováa, E AU - Stoeck, K AU - Sklaviadis, T AU - Kulczycki, J AU - Hess, K AU - Bodemer, M AU - Slivarichová, D AU - Saiz, A AU - Calero, M AU - Ingrosso, L AU - Knight, R AU - Janssens, AC AU - van Duijn, CM AU - Zerr, I PY - 2006/08/22/ UR - http://dx.doi.org/10.1212/01.wnl.0000230159.67128.00 ER -