Diagnostic Value of CSF Biomarker Profile in Frontotemporal Lobar Degeneration.

@article{citeulike:2476323, abstract = {BACKGROUND: Cerebrospinal fluid (CSF) biomarkers have been increasingly studied in dementia clinical and differential diagnosis. METHODS: We assessed levels of total tau protein (tauT), tau phosphorylated at threonine 181 (tauP-181), and beta-amyloid1-42 (Abeta42) in 34 patients with frontotemporal lobar degeneration (FTLD), 76 Alzheimer disease (AD) cases, and 93 controls (CTRL). Double sandwich enzyme-linked immunosorbent assays (Innogenetics) were used for measurements. RESULTS: Total tau was significantly increased and Abeta42 decreased in FTLD and AD patients as compared with CTRL. CSF tauP-181 levels were significantly increased only in AD. The tauT/Abeta42 ratio successfully discriminated FTLD from CTRL with a 86.7\% specificity and 80.6\% sensitivity, whereas the tauT alone was more specific (95.7\%) but less sensitive (64.75\%). For the discrimination of FTLD from AD, tauT/Abeta42 ratio was better (90.3\% sensitivity and 64.5\% specificity) compared with the other biomarkers alone or in combination, whereas tauP-181 was less sensitive but more specific (68.4\% and 85.7\%, respectively). Subtype analysis revealed that the most AD-like profile of biomarkers were observed in FTLD with motor neuron signs, whereas the most non-AD profile were observed in patients with primary progressive aphasia. CONCLUSIONS: Combined analysis of CSF biomarkers may be useful for the best possible antemortem discrimination of FTLD from AD.}, address = {Department of Neurology, School of Medicine, Athens National University, Eginition Hospital, Athens, Greece.}, author = {Kapaki, E. and Paraskevas, G. P. and Papageorgiou, S. G. and Bonakis, A. and Kalfakis, N. and Zalonis, I. and Vassilopoulos, D. }, citeulike-article-id = {2476323}, doi = {http://dx.doi.org/10.1097/WAD.0b013e3181610fea}, issn = {0893-0341}, journal = {Alzheimer Dis Assoc Disord}, keywords = {csf, ftd}, number = {1}, pages = {47--53}, posted-at = {2008-03-06 02:22:51}, priority = {4}, title = {Diagnostic Value of CSF Biomarker Profile in Frontotemporal Lobar Degeneration.}, url = {http://dx.doi.org/10.1097/WAD.0b013e3181610fea}, volume = {22}, year = {2008} }

TY - JOUR ID - citeulike:2476323 L3 - citeulike-article-id:2476323 N2 - BACKGROUND: Cerebrospinal fluid (CSF) biomarkers have been increasingly studied in dementia clinical and differential diagnosis. METHODS: We assessed levels of total tau protein (tauT), tau phosphorylated at threonine 181 (tauP-181), and beta-amyloid1-42 (Abeta42) in 34 patients with frontotemporal lobar degeneration (FTLD), 76 Alzheimer disease (AD) cases, and 93 controls (CTRL). Double sandwich enzyme-linked immunosorbent assays (Innogenetics) were used for measurements. RESULTS: Total tau was significantly increased and Abeta42 decreased in FTLD and AD patients as compared with CTRL. CSF tauP-181 levels were significantly increased only in AD. The tauT/Abeta42 ratio successfully discriminated FTLD from CTRL with a 86.7% specificity and 80.6% sensitivity, whereas the tauT alone was more specific (95.7%) but less sensitive (64.75%). For the discrimination of FTLD from AD, tauT/Abeta42 ratio was better (90.3% sensitivity and 64.5% specificity) compared with the other biomarkers alone or in combination, whereas tauP-181 was less sensitive but more specific (68.4% and 85.7%, respectively). Subtype analysis revealed that the most AD-like profile of biomarkers were observed in FTLD with motor neuron signs, whereas the most non-AD profile were observed in patients with primary progressive aphasia. CONCLUSIONS: Combined analysis of CSF biomarkers may be useful for the best possible antemortem discrimination of FTLD from AD. IS - 1 JF - Alzheimer Dis Assoc Disord SN - 0893-0341 AD - Department of Neurology, School of Medicine, Athens National University, Eginition Hospital, Athens, Greece. EP - 53 TI - Diagnostic Value of CSF Biomarker Profile in Frontotemporal Lobar Degeneration. VL - 22 SP - 47 KW - csf KW - ftd AU - Kapaki, E AU - Paraskevas, GP AU - Papageorgiou, SG AU - Bonakis, A AU - Kalfakis, N AU - Zalonis, I AU - Vassilopoulos, D PY - 2008///r UR - http://dx.doi.org/10.1097/WAD.0b013e3181610fea ER -