Synaptic influence of hippocampus on pyramidal cells of the rat prefrontal cortex: an in vivo intracellular recording study.

@article{Degenetais2003, abstract = {The hippocampus and prefrontal cortex are two structures implicated in learning and memory and are related through a direct excitatory pathway. The characteristics of the synaptic influence of the hippocampus on pyramidal cells of the prefrontal cortex were determined using intracellular recordings in anesthetized rats. Single-pulse stimulation of the hippocampus induced an early EPSP of fixed latency in most of the recorded pyramidal cells (n = 106/116) thereby demonstrating a monosynaptic connection between hippocampal neurons and pyramidal cells of the prefrontal cortex. Furthermore, the EPSP was followed by a prolonged IPSP and suggests a simultaneous engagement of pyramidal and non-pyramidal neurons that may ultimately constrain the spread of excitation in response to hippocampal input. Paired-pulse stimulation induced short-term modifications in the synaptic responses and this short-term plasticity may contribute to the temporal filtering of information. Finally, tetanic stimulation of the hippocampus produced long-term potentiation of the monosynaptic EPSP with a concomitant potentiation of the IPSP, indicating that the hippocampo-prefrontal network can participate in the formation and consolidation of memories. In conclusion, the characteristics of the synaptic transmission in the hippocampo-prefrontal cortex pathway further supports the existence of a cooperative relationship between two structures known to be involved in higher cognitive processes.}, address = {Chaire de Neuropharmacologie, INSERM U114, Coll\`{e}ge de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France.}, author = {D\'{e}gen\`{e}tais, E. and Thierry, A. M. and Glowinski, J. and Gioanni, Y. }, citeulike-article-id = {3023920}, issn = {1047-3211}, journal = {Cerebral cortex (New York, N.Y. : 1991)}, keywords = {pfc-hpc}, month = {July}, number = {7}, pages = {782--792}, posted-at = {2008-07-21 10:25:38}, priority = {2}, title = {Synaptic influence of hippocampus on pyramidal cells of the rat prefrontal cortex: an in vivo intracellular recording study.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12816894}, volume = {13}, year = {2003} }

TY - JOUR ID - Degenetais2003 L3 - citeulike-article-id:3023920 N2 - The hippocampus and prefrontal cortex are two structures implicated in learning and memory and are related through a direct excitatory pathway. The characteristics of the synaptic influence of the hippocampus on pyramidal cells of the prefrontal cortex were determined using intracellular recordings in anesthetized rats. Single-pulse stimulation of the hippocampus induced an early EPSP of fixed latency in most of the recorded pyramidal cells (n = 106/116) thereby demonstrating a monosynaptic connection between hippocampal neurons and pyramidal cells of the prefrontal cortex. Furthermore, the EPSP was followed by a prolonged IPSP and suggests a simultaneous engagement of pyramidal and non-pyramidal neurons that may ultimately constrain the spread of excitation in response to hippocampal input. Paired-pulse stimulation induced short-term modifications in the synaptic responses and this short-term plasticity may contribute to the temporal filtering of information. Finally, tetanic stimulation of the hippocampus produced long-term potentiation of the monosynaptic EPSP with a concomitant potentiation of the IPSP, indicating that the hippocampo-prefrontal network can participate in the formation and consolidation of memories. In conclusion, the characteristics of the synaptic transmission in the hippocampo-prefrontal cortex pathway further supports the existence of a cooperative relationship between two structures known to be involved in higher cognitive processes. IS - 7 JF - Cerebral cortex (New York, N.Y. : 1991) SN - 1047-3211 AD - Chaire de Neuropharmacologie, INSERM U114, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France. EP - 792 TI - Synaptic influence of hippocampus on pyramidal cells of the rat prefrontal cortex: an in vivo intracellular recording study. VL - 13 SP - 782 KW - pfc-hpc AU - Dégenètais, E AU - Thierry, AM AU - Glowinski, J AU - Gioanni, Y PY - 2003/07// UR - http://view.ncbi.nlm.nih.gov/pubmed/12816894 ER -