Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes.

@article{citeulike:325795, abstract = {There has been interest in the effect of various types and amounts of dietary carbohydrates and proteins on blood glucose. On the basis of our previous data, we designed a high-protein/low-carbohydrate, weight-maintaining, nonketogenic diet. Its effect on glucose control in people with untreated type 2 diabetes was determined. We refer to this as a low-biologically-available-glucose (LoBAG) diet. Eight men were studied using a randomized 5-week crossover design with a 5-week washout period. The carbohydrate:protein:fat ratio of the control diet was 55:15:30. The test diet ratio was 20:30:50. Plasma and urinary beta-hydroxybutyrate were similar on both diets. The mean 24-h integrated serum glucose at the end of the control and LoBAG diets was 198 and 126 mg/dl, respectively. The percentage of glycohemoglobin was 9.8 +/- 0.5 and 7.6 +/- 0.3, respectively. It was still decreasing at the end of the LoBAG diet. Thus, the final calculated glycohemoglobin was estimated to be approximately 6.3-5.4\%. Serum insulin was decreased, and plasma glucagon was increased. Serum cholesterol was unchanged. Thus, a LoBAG diet ingested for 5 weeks dramatically reduced the circulating glucose concentration in people with untreated type 2 diabetes. Potentially, this could be a patient-empowering way to ameliorate hyperglycemia without pharmacological intervention. The long-term effects of such a diet remain to be determined.}, address = {Metabolic Research Laboratory (111G), VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA. ganno004@umn.edu}, author = {Gannon, M. C. and Nuttall, F. Q. }, citeulike-article-id = {325795}, doi = {http://dx.doi.org/10.2337/diabetes.53.9.2375}, issn = {0012-1797}, journal = {Diabetes}, keywords = {blood, control, glucose, protein}, month = {September}, number = {9}, pages = {2375--2382}, posted-at = {2007-11-22 16:47:49}, priority = {3}, title = {Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes.}, url = {http://dx.doi.org/10.2337/diabetes.53.9.2375}, volume = {53}, year = {2004} }

TY - JOUR ID - citeulike:325795 L3 - citeulike-article-id:325795 N2 - There has been interest in the effect of various types and amounts of dietary carbohydrates and proteins on blood glucose. On the basis of our previous data, we designed a high-protein/low-carbohydrate, weight-maintaining, nonketogenic diet. Its effect on glucose control in people with untreated type 2 diabetes was determined. We refer to this as a low-biologically-available-glucose (LoBAG) diet. Eight men were studied using a randomized 5-week crossover design with a 5-week washout period. The carbohydrate:protein:fat ratio of the control diet was 55:15:30. The test diet ratio was 20:30:50. Plasma and urinary beta-hydroxybutyrate were similar on both diets. The mean 24-h integrated serum glucose at the end of the control and LoBAG diets was 198 and 126 mg/dl, respectively. The percentage of glycohemoglobin was 9.8 +/- 0.5 and 7.6 +/- 0.3, respectively. It was still decreasing at the end of the LoBAG diet. Thus, the final calculated glycohemoglobin was estimated to be approximately 6.3-5.4%. Serum insulin was decreased, and plasma glucagon was increased. Serum cholesterol was unchanged. Thus, a LoBAG diet ingested for 5 weeks dramatically reduced the circulating glucose concentration in people with untreated type 2 diabetes. Potentially, this could be a patient-empowering way to ameliorate hyperglycemia without pharmacological intervention. The long-term effects of such a diet remain to be determined. IS - 9 JF - Diabetes SN - 0012-1797 AD - Metabolic Research Laboratory (111G), VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA. ganno004@umn.edu EP - 2382 TI - Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes. VL - 53 SP - 2375 KW - blood KW - control KW - glucose KW - protein AU - Gannon, MC AU - Nuttall, FQ PY - 2004/09// UR - http://dx.doi.org/10.2337/diabetes.53.9.2375 ER -