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FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes

by: Fatima Al-Shahrour, Ramon Diaz-Uriarte, Joaquin Dopazo
Bioinformatics, Vol. 20, No. 4. (1 March 2004), pp. 578-580.


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Summary: We present a simple but powerful procedure to extract Gene Ontology (GO) terms that are significantly over- or under-represented in sets of genes within the context of a genome-scale experiment (DNA microarray, proteomics, etc.). Said procedure has been implemented as a web application, FatiGO, allowing for easy and interactive querying. FatiGO, which takes the multiple-testing nature of statistical contrast into account, currently includes GO associations for diverse organisms (human, mouse, fly, worm and yeast) and the TrEMBL/Swissprot GOAnnotations@EBI correspondences from the European Bioinformatics Institute. Availability: http://fatigo.bioinfo.cnio.es 10.1093/bioinformatics/btg455


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