Statistical distributions of nucleosomes: nonrandom locations by a stochastic mechanism.

by: RD Kornberg, L Stryer

Nucleic acids research, Vol. 16, No. 14A. (25 July 1988), pp. 6677-6690.

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Abstract

Expressions are derived for distributions of nucleosomes in chromatin. Nucleosomes are placed on DNA at the densities found in bulk chromatin, and their locations are allowed to vary at random. No further assumptions are required to simulate the periodic patterns of digestion obtained with various nucleases. The introduction of a boundary constraint, due for example to sequence-specific protein binding, results in an array of regularly spaced nucleosomes at nonrandom locations, similar to the arrays reported for some genes and other chromosomal regions.

@article{citeulike:2910670, abstract = {Expressions are derived for distributions of nucleosomes in chromatin. Nucleosomes are placed on DNA at the densities found in bulk chromatin, and their locations are allowed to vary at random. No further assumptions are required to simulate the periodic patterns of digestion obtained with various nucleases. The introduction of a boundary constraint, due for example to sequence-specific protein binding, results in an array of regularly spaced nucleosomes at nonrandom locations, similar to the arrays reported for some genes and other chromosomal regions.}, address = {Department of Cell Biology, Stanford University School of Medicine, CA 94305.}, author = {Kornberg, R. D. and Stryer, L. }, citeulike-article-id = {2910670}, issn = {0305-1048}, journal = {Nucleic acids research}, keywords = {nucleosome}, month = {July}, number = {14A}, pages = {6677--6690}, posted-at = {2008-06-20 16:20:32}, priority = {2}, title = {Statistical distributions of nucleosomes: nonrandom locations by a stochastic mechanism.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/3399412}, volume = {16}, year = {1988} }

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TY - JOUR ID - citeulike:2910670 L3 - citeulike-article-id:2910670 N2 - Expressions are derived for distributions of nucleosomes in chromatin. Nucleosomes are placed on DNA at the densities found in bulk chromatin, and their locations are allowed to vary at random. No further assumptions are required to simulate the periodic patterns of digestion obtained with various nucleases. The introduction of a boundary constraint, due for example to sequence-specific protein binding, results in an array of regularly spaced nucleosomes at nonrandom locations, similar to the arrays reported for some genes and other chromosomal regions. IS - 14A JF - Nucleic acids research SN - 0305-1048 AD - Department of Cell Biology, Stanford University School of Medicine, CA 94305. EP - 6690 TI - Statistical distributions of nucleosomes: nonrandom locations by a stochastic mechanism. VL - 16 SP - 6677 KW - nucleosome AU - Kornberg, RD AU - Stryer, L PY - 1988/07/25/ UR - http://view.ncbi.nlm.nih.gov/pubmed/3399412 ER -

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