Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures -- A short review

@article{citeulike:2971782, abstract = {In the last 25 years data has grown exponentially dealing with the discovery of the endocannabinoid system consisting of specific cannabinoid receptors, their endogenous ligands, and enzymatic systems of their biosynthesis and degradation. Progress is being made in the development of novel agonists and antagonists with receptor subtype selectivity which should help in providing a greater understanding of the physiological role of the endocannabinoid system and perhaps also in a broad number of pathologies. This could lead to advances with important therapeutic potential of drugs modulating activity of endocannabinoid system as hypnotics, analgesics, antiemetics, antiasthmatics, antihypertensives, immunomodulatory drugs, antiphlogistics, neuroprotective agents, antiepileptics, agents influencing glaucoma, spasticity and other "movement disorders", eating disorders, alcohol withdrawal, hepatic fibrosis, bone growth, and atherosclerosis. The aim of this review is to highlight distribution of the CB1 and CB2 receptor subtypes in the nervous system and functional involvement of their specific ligands.}, author = {Sv\'{i}zensk\'{a}, Ivana and Dubov\'{y}, Petr and Sulcov\'{a}, Alexandra }, citeulike-article-id = {2971782}, doi = {http://dx.doi.org/10.1016/j.pbb.2008.05.010}, journal = {Pharmacology Biochemistry and Behavior}, keywords = {cb1, human, review}, posted-at = {2008-07-08 09:38:54}, priority = {2}, title = {Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures -- A short review}, url = {http://dx.doi.org/10.1016/j.pbb.2008.05.010}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:2971782 L3 - citeulike-article-id:2971782 N2 - In the last 25 years data has grown exponentially dealing with the discovery of the endocannabinoid system consisting of specific cannabinoid receptors, their endogenous ligands, and enzymatic systems of their biosynthesis and degradation. Progress is being made in the development of novel agonists and antagonists with receptor subtype selectivity which should help in providing a greater understanding of the physiological role of the endocannabinoid system and perhaps also in a broad number of pathologies. This could lead to advances with important therapeutic potential of drugs modulating activity of endocannabinoid system as hypnotics, analgesics, antiemetics, antiasthmatics, antihypertensives, immunomodulatory drugs, antiphlogistics, neuroprotective agents, antiepileptics, agents influencing glaucoma, spasticity and other "movement disorders", eating disorders, alcohol withdrawal, hepatic fibrosis, bone growth, and atherosclerosis. The aim of this review is to highlight distribution of the CB1 and CB2 receptor subtypes in the nervous system and functional involvement of their specific ligands. JF - Pharmacology Biochemistry and Behavior TI - Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures -- A short review VL - In Press, Corrected Proof KW - cb1 KW - human KW - review AU - Svízenská, Ivana AU - Dubový, Petr AU - Sulcová, Alexandra UR - http://dx.doi.org/10.1016/j.pbb.2008.05.010 ER -