Epithelial stem cells: turning over new leaves.

by: C Blanpain, V Horsley, E Fuchs

Cell, Vol. 128, No. 3. (9 February 2007), pp. 445-458.

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Abstract

Most epithelial tissues self-renew throughout adult life due to the presence of multipotent stem cells and/or unipotent progenitor cells. Epithelial stem cells are specified during development and are controlled by epithelial-mesenchymal interactions. Despite morphological and functional differences among epithelia, common signaling pathways appear to control epithelial stem cell maintenance, activation, lineage determination, and differentiation. Additionally, deregulation of these pathways can lead to human disorders including cancer. Understanding epithelial stem cell biology has major clinical implications for the diagnosis, prevention, and treatment of human diseases, as well as for regenerative medicine.

@article{citeulike:1159112, abstract = {Most epithelial tissues self-renew throughout adult life due to the presence of multipotent stem cells and/or unipotent progenitor cells. Epithelial stem cells are specified during development and are controlled by epithelial-mesenchymal interactions. Despite morphological and functional differences among epithelia, common signaling pathways appear to control epithelial stem cell maintenance, activation, lineage determination, and differentiation. Additionally, deregulation of these pathways can lead to human disorders including cancer. Understanding epithelial stem cell biology has major clinical implications for the diagnosis, prevention, and treatment of human diseases, as well as for regenerative medicine.}, address = {Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA.}, author = {Blanpain, C. and Horsley, V. and Fuchs, E. }, citeulike-article-id = {1159112}, doi = {10.1016/j.cell.2007.01.014}, issn = {0092-8674}, journal = {Cell}, keywords = {biology, cancer}, month = {February}, number = {3}, pages = {445--458}, posted-at = {2007-03-14 07:11:09}, priority = {2}, title = {Epithelial stem cells: turning over new leaves.}, url = {http://dx.doi.org/10.1016/j.cell.2007.01.014}, volume = {128}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1159112 L3 - citeulike-article-id:1159112 TI - Epithelial stem cells: turning over new leaves. JF - Cell VL - 128 IS - 3 SP - 445 EP - 458 AD - Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA. SN - 0092-8674 N2 - Most epithelial tissues self-renew throughout adult life due to the presence of multipotent stem cells and/or unipotent progenitor cells. Epithelial stem cells are specified during development and are controlled by epithelial-mesenchymal interactions. Despite morphological and functional differences among epithelia, common signaling pathways appear to control epithelial stem cell maintenance, activation, lineage determination, and differentiation. Additionally, deregulation of these pathways can lead to human disorders including cancer. Understanding epithelial stem cell biology has major clinical implications for the diagnosis, prevention, and treatment of human diseases, as well as for regenerative medicine. KW - biology KW - cancer AU - Blanpain, C AU - Horsley, V AU - Fuchs, E PY - 2007/02/09/ UR - http://dx.doi.org/10.1016/j.cell.2007.01.014 ER -

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