The epigenomics of cancer.

by: PA Jones, SB Baylin

Cell, Vol. 128, No. 4. (23 February 2007), pp. 683-692.

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Abstract

Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.

@article{citeulike:1159111, abstract = {Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.}, address = {Department of Urology, Biochemistry, and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. jones\_p@ccnt.usc.edu}, author = {Jones, P. A. and Baylin, S. B. }, citeulike-article-id = {1159111}, doi = {10.1016/j.cell.2007.01.029}, issn = {0092-8674}, journal = {Cell}, keywords = {biology, cancer}, month = {February}, number = {4}, pages = {683--692}, posted-at = {2007-03-14 07:10:56}, priority = {2}, title = {The epigenomics of cancer.}, url = {http://dx.doi.org/10.1016/j.cell.2007.01.029}, volume = {128}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1159111 L3 - citeulike-article-id:1159111 TI - The epigenomics of cancer. JF - Cell VL - 128 IS - 4 SP - 683 EP - 692 AD - Department of Urology, Biochemistry, and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. jones_p@ccnt.usc.edu SN - 0092-8674 N2 - Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer. KW - biology KW - cancer AU - Jones, PA AU - Baylin, SB PY - 2007/02/23/ UR - http://dx.doi.org/10.1016/j.cell.2007.01.029 ER -

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