Evolvability is a selectable trait.

by: DJ Earl, MW Deem

Proc Natl Acad Sci U S A, Vol. 101, No. 32. (10 August 2004), pp. 11531-11536.

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Abstract

Concomitant with the evolution of biological diversity must have been the evolution of mechanisms that facilitate evolution, because of the essentially infinite complexity of protein sequence space. We describe how evolvability can be an object of Darwinian selection, emphasizing the collective nature of the process. We quantify our theory with computer simulations of protein evolution. These simulations demonstrate that rapid or dramatic environmental change leads to selection for greater evolvability. The selective pressure for large-scale genetic moves such as DNA exchange becomes increasingly strong as the environmental conditions become more uncertain. Our results demonstrate that evolvability is a selectable trait and allow for the explanation of a large body of experimental results.

@article{citeulike:93311, abstract = {Concomitant with the evolution of biological diversity must have been the evolution of mechanisms that facilitate evolution, because of the essentially infinite complexity of protein sequence space. We describe how evolvability can be an object of Darwinian selection, emphasizing the collective nature of the process. We quantify our theory with computer simulations of protein evolution. These simulations demonstrate that rapid or dramatic environmental change leads to selection for greater evolvability. The selective pressure for large-scale genetic moves such as DNA exchange becomes increasingly strong as the environmental conditions become more uncertain. Our results demonstrate that evolvability is a selectable trait and allow for the explanation of a large body of experimental results.}, address = {Department of Bioengineering, Rice University, Houston, TX 77005-1892, USA.}, author = {Earl, D. J. and Deem, M. W. }, citeulike-article-id = {93311}, doi = {http://dx.doi.org/10.1073/pnas.0404656101}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {evolution, evolvability}, month = {August}, number = {32}, pages = {11531--11536}, posted-at = {2005-02-11 16:05:45}, priority = {2}, title = {Evolvability is a selectable trait.}, url = {http://dx.doi.org/10.1073/pnas.0404656101}, volume = {101}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:93311 L3 - citeulike-article-id:93311 TI - Evolvability is a selectable trait. JF - Proc Natl Acad Sci U S A VL - 101 IS - 32 SP - 11531 EP - 11536 AD - Department of Bioengineering, Rice University, Houston, TX 77005-1892, USA. SN - 0027-8424 N2 - Concomitant with the evolution of biological diversity must have been the evolution of mechanisms that facilitate evolution, because of the essentially infinite complexity of protein sequence space. We describe how evolvability can be an object of Darwinian selection, emphasizing the collective nature of the process. We quantify our theory with computer simulations of protein evolution. These simulations demonstrate that rapid or dramatic environmental change leads to selection for greater evolvability. The selective pressure for large-scale genetic moves such as DNA exchange becomes increasingly strong as the environmental conditions become more uncertain. Our results demonstrate that evolvability is a selectable trait and allow for the explanation of a large body of experimental results. KW - evolution KW - evolvability AU - Earl, DJ AU - Deem, MW PY - 2004/08/10/ UR - http://dx.doi.org/10.1073/pnas.0404656101 ER -

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