Regional and strain-specific gene expression mapping in the adult mouse brain.

@article{citeulike:942309, abstract = {To determine the genetic causes and molecular mechanisms responsible for neurobehavioral differences in mice, we used highly parallel gene expression profiling to detect genes that are differentially expressed between the 129SvEv and C57BL/6 mouse strains at baseline and in response to seizure. In addition, we identified genes that are differentially expressed in specific brain regions. We found that approximately 1\% of expressed genes are differentially expressed between strains in at least one region of the brain and that the gene expression response to seizure is significantly different between the two inbred strains. The results lead to the identification of differences in gene expression that may account for distinct phenotypes in inbred strains and the unique functions of specific brain regions.}, address = {The Salk Institute for Biological Studies, The Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.}, author = {Sandberg, R. and Yasuda, R. and Pankratz, D. G. and Carter, T. A. and Del Rio, J. A. and Wodicka, L. and Mayford, M. and Lockhart, D. J. and Barlow, C. }, citeulike-article-id = {942309}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {cis\_trans}, month = {September}, number = {20}, pages = {11038--11043}, posted-at = {2007-08-02 00:06:10}, priority = {2}, title = {Regional and strain-specific gene expression mapping in the adult mouse brain.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11005875}, volume = {97}, year = {2000} }

TY - JOUR ID - citeulike:942309 L3 - citeulike-article-id:942309 TI - Regional and strain-specific gene expression mapping in the adult mouse brain. JF - Proc Natl Acad Sci U S A VL - 97 IS - 20 SP - 11038 EP - 11043 AD - The Salk Institute for Biological Studies, The Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. SN - 0027-8424 N2 - To determine the genetic causes and molecular mechanisms responsible for neurobehavioral differences in mice, we used highly parallel gene expression profiling to detect genes that are differentially expressed between the 129SvEv and C57BL/6 mouse strains at baseline and in response to seizure. In addition, we identified genes that are differentially expressed in specific brain regions. We found that approximately 1% of expressed genes are differentially expressed between strains in at least one region of the brain and that the gene expression response to seizure is significantly different between the two inbred strains. The results lead to the identification of differences in gene expression that may account for distinct phenotypes in inbred strains and the unique functions of specific brain regions. KW - cis_trans AU - Sandberg, R AU - Yasuda, R AU - Pankratz, DG AU - Carter, TA AU - Del Rio, JA AU - Wodicka, L AU - Mayford, M AU - Lockhart, DJ AU - Barlow, C PY - 2000/09/26/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11005875 ER -