ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of Regulation

@article{lopez1998, abstract = {Abstract Alternative splicing of pre-mRNAs is a powerful and versatile regulatory mechanism that can effect quantitative control of gene expression and functional diversification of proteins. It contributes to major developmental decisions and also to fine tuning of gene function. Genetic and biochemical approaches have identified cis-acting regulatory elements and trans-acting factors that control alternative splicing of specific pre-mRNAs. Both approaches are contributing to an understanding of their mode of action. Some alternative splicing decisions are controlled by specific factors whose expression is highly restricted during development, but others may be controlled by more modest variations in the levels of general factors acting cooperatively or antagonistically. Certain factors play active roles in both constitutive splicing and regulation of alternative splicing. Cooperative and antagonistic effects integrated at regulatory elements are likely to be important for specificity and for finely tuned differences in cell-type-specific alternative splicing patterns.}, author = {Lopez, Javier A. }, citeulike-article-id = {3171461}, doi = {http://dx.doi.org/10.1146/annurev.genet.32.1.279}, journal = {Annual Review of Genetics}, keywords = {summer2008}, number = {1}, pages = {279--305}, posted-at = {2008-08-29 10:08:47}, priority = {2}, title = {ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of Regulation}, url = {http://dx.doi.org/10.1146/annurev.genet.32.1.279}, volume = {32}, year = {1998} }

TY - JOUR ID - lopez1998 L3 - citeulike-article-id:3171461 N2 - Abstract Alternative splicing of pre-mRNAs is a powerful and versatile regulatory mechanism that can effect quantitative control of gene expression and functional diversification of proteins. It contributes to major developmental decisions and also to fine tuning of gene function. Genetic and biochemical approaches have identified cis-acting regulatory elements and trans-acting factors that control alternative splicing of specific pre-mRNAs. Both approaches are contributing to an understanding of their mode of action. Some alternative splicing decisions are controlled by specific factors whose expression is highly restricted during development, but others may be controlled by more modest variations in the levels of general factors acting cooperatively or antagonistically. Certain factors play active roles in both constitutive splicing and regulation of alternative splicing. Cooperative and antagonistic effects integrated at regulatory elements are likely to be important for specificity and for finely tuned differences in cell-type-specific alternative splicing patterns. IS - 1 JF - Annual Review of Genetics EP - 305 TI - ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of Regulation VL - 32 SP - 279 KW - summer2008 AU - Lopez, Javier PY - 1998/// UR - http://dx.doi.org/10.1146/annurev.genet.32.1.279 ER -