Transcriptional regulatory networks in Saccharomyces cerevisiae.

by: TI Lee, NJ Rinaldi, F Robert, DT Odom, Z Bar-Joseph, GK Gerber, NM Hannett, CT Harbison, CM Thompson, I Simon, J Zeitlinger, EG Jennings, HL Murray, DB Gordon, B Ren, JJ Wyrick, JB Tagne, TL Volkert, E Fraenkel, DK Gifford, RA Young

Science, Vol. 298, No. 5594. (25 October 2002), pp. 799-804.

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Abstract

We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators.

@article{citeulike:2107, abstract = {We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators.}, address = {Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.}, author = {Lee, T. I. and Rinaldi, N. J. and Robert, F. and Odom, D. T. and Bar-Joseph, Z. and Gerber, G. K. and Hannett, N. M. and Harbison, C. T. and Thompson, C. M. and Simon, I. and Zeitlinger, J. and Jennings, E. G. and Murray, H. L. and Gordon, D. B. and Ren, B. and Wyrick, J. J. and Tagne, J. B. and Volkert, T. L. and Fraenkel, E. and Gifford, D. K. and Young, R. A. }, citeulike-article-id = {2107}, doi = {http://dx.doi.org/10.1126/science.1075090}, issn = {1095-9203}, journal = {Science}, keywords = {chip, network, regulatory\_network}, month = {October}, number = {5594}, pages = {799--804}, posted-at = {2008-07-07 15:58:32}, priority = {2}, title = {Transcriptional regulatory networks in Saccharomyces cerevisiae.}, url = {http://dx.doi.org/10.1126/science.1075090}, volume = {298}, year = {2002} }

RIS record

TY - JOUR ID - citeulike:2107 L3 - citeulike-article-id:2107 TI - Transcriptional regulatory networks in Saccharomyces cerevisiae. JF - Science VL - 298 IS - 5594 SP - 799 EP - 804 AD - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. SN - 1095-9203 N2 - We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators. KW - chip KW - network KW - regulatory_network AU - Lee, TI AU - Rinaldi, NJ AU - Robert, F AU - Odom, DT AU - Bar-Joseph, Z AU - Gerber, GK AU - Hannett, NM AU - Harbison, CT AU - Thompson, CM AU - Simon, I AU - Zeitlinger, J AU - Jennings, EG AU - Murray, HL AU - Gordon, DB AU - Ren, B AU - Wyrick, JJ AU - Tagne, JB AU - Volkert, TL AU - Fraenkel, E AU - Gifford, DK AU - Young, RA PY - 2002/10/25/ UR - http://dx.doi.org/10.1126/science.1075090 ER -

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