Gene silencing in severe systemic inflammation.

@article{citeulike:2144519, abstract = {This critical care perspective appraises reprogramming of gene expression in inflammatory diseases as an emerging concept of clinical importance. We emphasize gene reprogramming that "silences" acute proinflammatory genes during severe systemic inflammation, wherein in the systemic inflammatory response syndrome (SIRS) exists as a continuum during severe sepsis, septic shock, and the multiorgan dysfunction and failure phenotypes without infection. In contrast, silencing of acute proinflammatory genes is not apparent in sites of localized inflammatory processes like rheumatoid arthritis. We discuss in three parts the clinical context and the translational basic science associated with gene silencing during the SIRS continuum of severe systemic inflammation: (1) reprogramming of acute proinflammatory genes; (2) a "nuclear factor-kappaB paradox," coupled with RelB expression, that combine to silence genes using an epigenetic (inherited and reversible) signature on the nucleosome; and (3) the potential clinical importance of compartmentalization in gene silencing. Our emergent understanding of these physiologic processes may provide a novel framework for developing treatments.}, address = {Section of Molecular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1042, USA. chmccall@wfubmc.edu}, author = {McCall, C. E. and Yoza, B. K. }, citeulike-article-id = {2144519}, doi = {http://dx.doi.org/10.1164/rccm.200610-1436CP}, issn = {1073-449X}, journal = {Am J Respir Crit Care Med}, month = {April}, number = {8}, pages = {763--767}, posted-at = {2007-12-19 07:27:56}, priority = {2}, title = {Gene silencing in severe systemic inflammation.}, url = {http://dx.doi.org/10.1164/rccm.200610-1436CP}, volume = {175}, year = {2007} }

TY - JOUR ID - citeulike:2144519 L3 - citeulike-article-id:2144519 TI - Gene silencing in severe systemic inflammation. JF - Am J Respir Crit Care Med VL - 175 IS - 8 SP - 763 EP - 767 AD - Section of Molecular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1042, USA. chmccall@wfubmc.edu SN - 1073-449X N2 - This critical care perspective appraises reprogramming of gene expression in inflammatory diseases as an emerging concept of clinical importance. We emphasize gene reprogramming that "silences" acute proinflammatory genes during severe systemic inflammation, wherein in the systemic inflammatory response syndrome (SIRS) exists as a continuum during severe sepsis, septic shock, and the multiorgan dysfunction and failure phenotypes without infection. In contrast, silencing of acute proinflammatory genes is not apparent in sites of localized inflammatory processes like rheumatoid arthritis. We discuss in three parts the clinical context and the translational basic science associated with gene silencing during the SIRS continuum of severe systemic inflammation: (1) reprogramming of acute proinflammatory genes; (2) a "nuclear factor-kappaB paradox," coupled with RelB expression, that combine to silence genes using an epigenetic (inherited and reversible) signature on the nucleosome; and (3) the potential clinical importance of compartmentalization in gene silencing. Our emergent understanding of these physiologic processes may provide a novel framework for developing treatments. AU - McCall, CE AU - Yoza, BK PY - 2007/04/15/ UR - http://dx.doi.org/10.1164/rccm.200610-1436CP ER -