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Tag pharmacology [210 articles]

Recent papers classified by the tag pharmacology.
  • G-protein-coupled receptor heterodimers: pharmacology, function and relevance to drug discovery
    Drug Discovery Today, Vol. 11, No. 11-12. (June 2006), pp. 541-549.
    by G Milligan
    posted to signalling pharmacology heterodimer gpcr by zimbo1 on 2008-10-21 11:18:02 as **
  • RNAi therapeutics: Principles, prospects and challenges
    Advanced Drug Delivery Reviews, Vol. 59, No. 2-3. (30 March 2007), pp. 75-86.
    by Lars Aagaard, John J Rossi
    posted to cancer pharmacology review by xtizon on 2008-02-17 20:17:50 as ** along with 1 person psique
  • Defining the Role of mTOR in Cancer
    Cancer Cell, Vol. 12, No. 1. (10 July 2007), pp. 9-22.
    by David A Guertin, David M Sabatini
    posted to cancer pharmacology review by xtizon on 2008-02-17 20:19:05 as ** along with 1 person voldog
  • The evasive nature of drug efficacy: implications for drug discovery
    Trends in Pharmacological Sciences, Vol. 28, No. 8. (August 2007), pp. 423-430.
    by Segolene Galandrin, Genevieve Oligny-Longpre, Michel Bouvier
    posted to pharmacology review by xtizon on 2008-02-17 20:16:43 as ** along with 1 person guhjy
  • A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding.
    Drug Discov Today, Vol. 12, No. 15-16. (August 2007), pp. 622-633.
    by Marie A A Bogoyevitch, David P P Fairlie
    posted to cancer drug pharmacology by xtizon on 2008-02-17 19:49:02 as ** along with 3 people bicko higueruelo zimbo1
  • The Endocannabinoid System as an Emerging Target of Pharmacotherapy
    Pharmacol Rev, Vol. 58, No. 3. (1 September 2006), pp. 389-462.
    by Pal Pacher, Sandor Batkai, George Kunos
    posted to cannabinoid cannabis endocannabinoid marijuana pharmacology pharmacotherapy system treatment by xico on 2006-11-27 18:20:44 as **** along with 1 group WetBiology
  • The endocannabinoid system: physiology and pharmacology.
    Alcohol Alcohol, Vol. 40, No. 1. (b 2005), pp. 2-14.
    by F Rodríguez de Fonseca, I Del Arco, FJ Bermudez-Silva, A Bilbao, A Cippitelli, M Navarro
    posted to anandamide cannabis endocannabinoid pharmacology physiology by xico on 2007-08-21 16:12:44 as read along with 1 group WetBiology
  • Cannabinoid pharmacology: the first 66 years.
    Br J Pharmacol, Vol. 147 Suppl 1 (January 2006)
    by RG Pertwee
    posted to cannabinoid cb1 cb2 pharmacology receptor review system by xico on 2006-11-27 18:51:36 as **** along with 1 person and 1 group kimbellanderson WetBiology
  • Pharmacological inhibitors of cyclin-dependent kinases.
    Trends Pharmacol Sci, Vol. 23, No. 9. (September 2002), pp. 417-425.
    by M Knockaert, P Greengard, L Meijer
    posted to cdk cell cycle cyclin inhibitor kinase pharmacology small transcription by xico on 2007-02-13 01:44:23 as ** along with 1 group WetBiology
  • I want a new drug: G-protein-coupled receptors in drug development.
    Drug Discov Today, Vol. 11, No. 11-12. (June 2006), pp. 481-493.
    by S Schlyer, R Horuk
    posted to drug gpcr ligands pharmacology review by xdeupi on 2006-11-04 12:41:53 as ** along with 1 person and 1 group zimbo1 LabCompMed
  • GPCR agonists and antagonists in the clinic.
    Med Chem, Vol. 1, No. 4. (July 2005), pp. 405-421.
    by JD Tyndall, R Sandilya
    posted to agonist drug gpcr ligands pharmacology by xdeupi on 2006-07-24 10:18:01 as ** along with 1 group LabCompMed
  • Physiological relevance of GPCR oligomerization and its impact on drug discovery
    Drug Discovery Today (14 October 2008)
    by R Panetta, M Greenwood
    posted to review pharmacology ligands gpcr drug disease dimer by xdeupi on 2008-10-16 09:57:50 as **
  • Recruitment of beta-arrestin2 to the dopamine D2 receptor: Insights into anti-psychotic and anti-parkinsonian drug receptor signaling.
    Neuropharmacology (8 April 2008)
    by Ib V V Klewe, Søren M M Nielsen, Louise Tarpø, Eneko Urizar, Concetta Dipace, Jonathan A A Javitch, Ulrik Gether, Jan Egebjerg, Kenneth V V Christensen
    posted to activation active-state agonist arrestin biased_agonism binding disease fluorescence imaging internalization pharmacology by xdeupi on 2008-05-13 16:24:49 as **
  • Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
    The EMBO Journal, Vol. aop, No. current. (14 December 2006)
    by Yutong Sun, Jianyun Huang, Yang Xiang, Murat Bastepe, Harald Juppner, Brian K Kobilka, Jillian J Zhang, Xin-Yun Huang
    posted to activation b2ar drug pharmacology switch by xdeupi on 2007-03-21 11:13:23 as ** along with 1 person and 1 group Guff32 LabCompMed
  • Smart drug discovery leveraging innovative technologies and predictive knowledge.
    Nat Chem Biol, Vol. 2, No. 12. (December 2006), pp. 646-648.
    by TK Sawyer
    posted to drug pharmacology by xdeupi on 2007-04-23 16:56:56 as ** along with 1 group LabCompMed
  • Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor.
    J Comput Aided Mol Des (13 October 2006)
    by Stanley R Krystek, S R Kimura, Andrew J Tebben
    posted to b2ar binding drug ligands modeling pharmacology by xdeupi on 2006-10-27 09:43:03 as ** along with 1 person and 1 group daevans LabCompMed
  • Clinical consequences of ADR2 polymorphisms
    Pharmacogenomics, Vol. 9, No. 3. (March 2008), pp. 349-358.
    by Hawkins, A Gregory, Weiss, T Scott, Bleecker, R Eugene
    posted to b2ar disease drug genome pharmacology polymorphism review by xdeupi on 2008-05-03 17:12:39 as **
  • Data-Driven Analysis in Drug Discovery
    Journal of Receptors and Signal Transduction, Vol. 26, No. 4. (August 2006), pp. 299-327.
    by Terry Kenakin
    posted to agonist binding drug ligands pharmacology by xdeupi on 2006-07-17 16:28:05 as **** along with 1 group LabCompMed
  • Heterologous Expression of the Adenosine A1 Receptor in Transgenic Mouse Retina.
    Biochemistry (20 June 2007)
    by Ning Li, David Salom, Li Zhang, Tim Harris, Juan A Ballesteros, Marcin Golczak, Beata Jastrzebska, Krzysztof Palczewski, Carole Kurahara, Todd Juan, Steven Jordan, John A Salon
    posted to expression gpcr pharmacology by xdeupi on 2007-06-25 10:09:54 as ** along with 1 group LabCompMed
  • Functional selectivity and classical concepts of quantitative pharmacology.
    J Pharmacol Exp Ther (27 June 2006)
    by Jonathan D D Urban, William P P Clarke, Mark von Zastrow, David E E Nichols, Brian K K Kobilka, Harel Weinstein, Jonathan A A Javitch, Bryan L L Roth, Arthur Christopoulos, Patrick Sexton, Keith Miller, Michael Spedding, Richard B B Mailman
    posted to activation b2ar pharmacology review switch by xdeupi on 2006-09-07 15:43:50 as ***** along with 2 people and 1 group shoshin kentsis LabCompMed
  • Recent advances in identification and characterization of beta-adrenoceptor agonists and antagonists.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 207-216.
    by JP Hieble
    posted to agonist b2ar drug ligands pharmacology by xdeupi on 2007-03-12 14:32:04 as ** along with 1 group LabCompMed
  • G proteins in drug screening: from analysis of receptor-G protein specificity to manipulation of GPCR-mediated signalling pathways.
    Curr Pharm Des, Vol. 12, No. 14. (2006), pp. 1703-1715.
    by E Kostenis
    posted to activation cterm drug ecl2 gpcr gproteins pharmacology by xdeupi on 2006-09-05 09:59:05 as **** along with 1 group LabCompMed
  • Chemical Biology & Drug Design: First Anniversary - 2007!
    Chem Biol Drug Des, Vol. 69, No. 1. (January 2007), pp. 1-2.
    by Tomi K K Sawyer
    posted to drug pharmacology review by xdeupi on 2007-04-23 16:56:17 as ** along with 1 group LabCompMed
  • G-protein-coupled receptor signalling through protein networks.
    Biochem Soc Trans, Vol. 35, No. Pt 1. (February 2007), pp. 23-27.
    by AD Strosberg, C Nahmias
    posted to b2ar gpcr pharmacology review structure by xdeupi on 2007-06-29 21:10:57 as ** along with 1 group LabCompMed
  • Chemogenomic approaches to rational drug design
    Br J Pharmacol, Vol. 152, No. 1. (29 May 2007), pp. 38-52.
    by D Rognan
    posted to agonist binding drug ligands pharmacology priviledged_structures by xdeupi on 2008-03-28 15:54:47 as ** along with 4 people and 3 groups jmrivort jerome_ucsf_slb guhjy tjimenez LabCompMed G-quadruplex Supramolecular
  • Subclassification and nomenclature of alpha- and beta-adrenoceptors.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 129-134.
    by JP Hieble
    posted to agonist b2ar drug genome ligands pharmacology review by xdeupi on 2007-03-12 14:33:19 as ** along with 1 group LabCompMed
  • Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein-Coupled Receptor Signaling.
    PLoS Comput Biol, Vol. 3, No. 1. (12 January 2007)
    by Tamara L L Kinzer-Ursem, Jennifer J J Linderman
    posted to activation agonist b2ar pharmacology by xdeupi on 2007-02-13 15:38:17 as **** along with 1 group LabCompMed
  • "Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology.
    Biochem Pharmacol, Vol. 73, No. 6. (15 March 2007), pp. 737-751.
    by CP Nelson, RA Challiss
    posted to agonist gpcr ligands pharmacology by xdeupi on 2007-04-10 18:54:26 as ** along with 1 person and 2 groups Fritz neurolit LabCompMed
  • Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.
    J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125.
    by B Behr, C Hoffmann, G Ottolina, KN Klotz
    posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi on 2006-09-05 11:05:20 as *** along with 1 group LabCompMed
  • beta-Arrestin-biased Agonism at the beta2-Adrenergic Receptor.
    J Biol Chem, Vol. 283, No. 9. (29 February 2008), pp. 5669-5676.
    by MT Drake, JD Violin, EJ Whalen, JW Wisler, SK Shenoy, RJ Lefkowitz
    posted to activation agonist arrestin b2ar biased_agonism drug gproteins imaging internalization ligands pharmacology by xdeupi on 2008-02-27 10:39:07 as *** along with 1 group LabCompMed
  • Multiple signaling states of G-protein-coupled receptors.
    Pharmacol Rev, Vol. 57, No. 2. (June 2005), pp. 147-161.
    by DM Perez, SS Karnik
    posted to activation agonist gpcr pharmacology review rhodopsin switch by xdeupi on 2007-04-26 14:57:25 as ***** along with 1 group LabCompMed
  • Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists.
    J Pharmacol Exp Ther (20 July 2006)
    by Terry P P Kenakin, Stephen Jenkinson, Christian Watson
    posted to activation drug ligands agonist pharmacology by xdeupi on 2006-09-05 09:51:58 as **** along with 1 group LabCompMed
  • Functional assays as prismatic views of drug activity: relevance to new drug discovery.
    Journal of receptor and signal transduction research, Vol. 28, No. 1. (2008), pp. 109-125.
    by T Kenakin
    posted to biased_agonism chemokine drug pharmacology review by xdeupi on 2008-05-03 17:03:08 as **
  • An essential role for orexins in emergence from general anesthesia
    Proceedings of the National Academy of Sciences, Vol. 105, No. 4. (29 January 2008), pp. 1309-1314.
    by Max B Kelz, Yi Sun, Jingqiu Chen, Cheng, Jason T Moore, Sigrid C Veasey, Shelley Dixon, Marcus Thornton, Hiromasa Funato, Masashi Yanagisawa
    posted to anaesthesia pharmacology by weis on 2008-03-24 18:58:47 as **
  • Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets.
    Fundam Clin Pharmacol, Vol. 18, No. 5. (October 2004), pp. 525-529.
    by H Rchid, H Chevassus, R Nmila, C Guiral, P Petit, M Chokaïri, Y Sauvaire
    posted to glucose nigella pharmacology seed by tsalman on 2004-11-22 11:02:54
  • notes Behavioral, physiological and functional aspects of stereotyped behavior: a review and a re-interpretation.
    J Anim Sci, Vol. 62, No. 6. (June 1986), pp. 1776-1786.
    by R Dantzer
    posted to hardcopy measurement pharmacology review stereotypy by tobymart on 2005-06-30 04:35:59 as read
  • Studies on the mechanism of action of avermectin B1a: Stimulation of release of GABA from brain synaptosomes.
    Journal of Neurochemistry, Vol. 34 (1980), pp. 351-358.
    by SS Pong, CC Wang, LC Fritz
    posted to wormbase synapse pharmacology neurotransmitter nematode inhib-miscellaneous elegans comp-vertebrate celegans caenorhabditis_elegans c_elegans article by tharris on 2008-09-16 18:09:00 as *** along with 1 group C. elegans / WormBase
  • Some effects of piperazine and methyridine on the free-living nematode C. briggsae (Rhabditidae).
    Nematologica, Vol. 13 (1967), pp. 241-255.
    posted to wormbase pharmacology nematode mut-drug_sensitivity inhib-miscellaneous elegans celegans caenorhabditis_elegans c_elegans c_briggsae article by tharris on 2008-09-16 17:39:40 as *** along with 1 group C. elegans / WormBase
  • Indolealkylamines in the coordination of nematode behavioral activities.
    Canadian Journal of Zoology, Vol. 53 (1975), pp. 894-903.
    posted to wormbase pharmacology neurotransmitter nematode elegans celegans caenorhabditis_elegans c_elegans biogenic_amine behav-movement article by tharris on 2008-09-16 17:34:08 as *** along with 1 group C. elegans / WormBase
  • Egg-laying defective mutants of the nematode C. elegans.
    Genetics, Vol. 104 (1983), pp. 619-647.
    by C Trent, N Tsung, HR Horvitz
    posted to wormbase sex_differences pharmacology nematode mutant_characteriz mut-behavioral genetic_map elegans celegans caenorhabditis_elegans c_elegans behav-egg-laying article by tharris on 2008-09-16 18:36:25 as *** along with 1 group C. elegans / WormBase
  • Initiation of spermiogenesis in C. elegans: A pharmacological and genetic analysis.
    Developmental Biology, Vol. 134 (1989), pp. 189-200.
    by DC Shakes, S Ward
    posted to wormbase ultrastructure-tem trifluoperazine_pharmacology t02e11 sulfonamides_pharmacology spermatozoa_physiology spermatogenesis_drug_effects spermatids_ultrastructure spermatids_physiology spermatids_drug_effects sperm_motility sperm-spermatogen spe-8 spe-12 pronase_pharmacology pharmacology nematode mutation mut-fertilization monensin_pharmacology microscopy_electron hydrogen_ion_concentration hermaphroditism f53g126 ethanolamines_pharmacology elegans chlorpromazine_pharmacology celegans caenorhabditis_physiology caenorhabditis_genetics caenorhabditis_elegans c_elegans behav-movement article ackn_cgc by tharris on 2008-09-16 20:12:43 as *** along with 1 group C. elegans / WormBase
  • The effects of amidantel (Bay d 8815) and its deacylated derivative (Bay d 9216) on C. elegans.
    European Journal of Pharmacology, Vol. 113 (1985), pp. 255-262.
    by GA Tomlinson, CA Albuquerque, RA Woods
    posted to wormbase receptor pharmacology neurotransmitter nematode inhib-enzyme inhib-anthelminthic enz-acetylcholine elegans celegans caenorhabditis_elegans c_elegans article by tharris on 2008-09-16 19:09:54 as *** along with 1 group C. elegans / WormBase
  • The effects of amidantel (Bay d 8815) and its deacylated derivative (Bay d 9216) on wild-type and resistant mutants of C. elegans.
    Canadian Journal of Zoology, Vol. 64 (1986), pp. 1310-1316.
    by RA Woods, KMB Malone, CA Albuquerque, GA Tomlinson
    posted to wormbase receptor pharmacology neurotransmitter nematode mut-drug_sensitivity inhib-anthelminthic elegans development celegans caenorhabditis_elegans c_elegans article by tharris on 2008-09-16 19:26:31 as *** along with 1 group C. elegans / WormBase
  • Cholinergic receptor mutants of the nematode C. elegans.
    Journal of Neuroscience, Vol. 7 (1987), pp. 3059-3071.
    by JA Lewis, JS Elmer, J Skimming, SA Mclafferty, JT Fleming, T Mcgee
    posted to wormbase receptor pharmacology neurotransmitter neurochemistry nematode mut-drug_sensitivity inhib-anthelminthic elegans celegans caenorhabditis_elegans c_elegans article by tharris on 2008-09-16 19:41:00 as *** along with 1 group C. elegans / WormBase
  • Levamisole-resistant mutants of the nematode C. elegans appear to lack pharmacological acetylcholine receptors.
    Neuroscience, Vol. 5 (1980), pp. 967-989.
    by JA Lewis, CH Wu, JH Levine, H Berg
    posted to wormbase receptor pharmacology nematode mut-drug_sensitivity muscle inhib-anthelminthic elegans celegans caenorhabditis_elegans c_elegans article anesthetic by tharris on 2008-09-16 18:09:56 as *** along with 1 group C. elegans / WormBase
  • Immunosuppressive and cytotoxic properties of Nigella sativa.
    Phytother Res, Vol. 18, No. 5. (May 2004), pp. 395-398.
    by SN Islam, P Begum, T Ahsan, S Huque, M Ahsan
    posted to cancer immunity nigella pharmacology by Tariq on 2004-11-24 17:23:25
  • Enzyme immunoassay screening procedure for the synthetic anabolic estrogens and androgens diethylstilbestrol, nortestosterone, methyltestosterone and trenbolone in bovine urine.
    J Chromatogr, Vol. 489, No. 1. (7 April 1989), pp. 235-243.
    by G Degand, P Schmitz, G Maghuin-Rogister
    posted to androgens estrogens pharmacology screening by Tariq on 2004-12-01 11:41:06
  • Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology.
    J Clin Endocrinol Metab, Vol. 82, No. 8. (August 1997), pp. 2403-2409.
    by F Labrie, A Bélanger, L Cusan, B Candas
    posted to androgens metabolites pharmacology screening by Tariq on 2004-12-01 15:40:34 along with 1 person FW_Gibb
  • Novel yeast bioassay system for detection of androgenic and antiandrogenic compounds.
    Toxicol In Vitro, Vol. 17, No. 2. (April 2003), pp. 237-244.
    by HJ Lee, YS Lee, HB Kwon, K Lee
    posted to androgens pharmacology screening yeast by Tariq on 2004-12-01 11:42:45
  • Bioassay of inhibin-like activity using pituitary cells in vitro.
    J Endocrinol, Vol. 80, No. 1. (January 1979), pp. 91-102.
    by FH de Jong, SD Smith, HJ van der Molen
    posted to bioassay inhibin pharmacology screening by Tariq on 2004-12-03 10:13:24
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